Success Metrics

Clinical Success Rate
100.0%

Based on 9 completed trials

Completion Rate
100%(9/9)
Active Trials
24(63%)
Results Posted
44%(4 trials)

Phase Distribution

Ph phase_1
14
37%
Ph phase_2
15
39%
Ph phase_3
8
21%

Phase Distribution

14

Early Stage

15

Mid Stage

8

Late Stage

Phase Distribution37 total trials
Phase 1Safety & dosage
14(37.8%)
Phase 2Efficacy & side effects
15(40.5%)
Phase 3Large-scale testing
8(21.6%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

90.0%

9 of 10 finished

Non-Completion Rate

10.0%

1 ended early

Currently Active

24

trials recruiting

Total Trials

38

all time

Status Distribution
Active(28)
Completed(9)
Terminated(1)

Detailed Status

Active, not recruiting12
Recruiting12
Completed9
Not yet recruiting4
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
38
Active
24
Success Rate
100.0%
Most Advanced
Phase 3

Trials by Phase

Phase 114 (37.8%)
Phase 215 (40.5%)
Phase 38 (21.6%)

Trials by Status

completed924%
withdrawn13%
not_yet_recruiting411%
active_not_recruiting1232%
recruiting1232%

Recent Activity

Clinical Trials (38)

Showing 20 of 38 trialsScroll for more
NCT04736706Phase 3

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)

Active Not Recruiting
NCT07049926Phase 1

Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)

Recruiting
NCT06234605Phase 1

A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

Recruiting
NCT04626479Phase 1

Substudy 03A: A Study of Immune and Targeted Combination Therapies in Participants With First Line (1L) Renal Cell Carcinoma (MK-3475-03A)

Completed
NCT04626518Phase 1

Substudy 03B: A Study of Immune and Targeted Combination Therapies in Participants With Second Line Plus (2L+) Renal Cell Carcinoma (MK-3475-03B/KEYMAKER-U03)

Completed
NCT04924075Phase 2

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

Recruiting
NCT07489495Phase 3

A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)

Recruiting
NCT07840001Phase 2

Neoadjuvant Belzutifan Plus Pembrolizumab in High-Risk, Locally Advanced Clear Cell Renal Cell Carcinoma

Not Yet Recruiting
NCT04489771Phase 2

A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)

Completed
NCT07405164Phase 3

Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)

Recruiting
NCT02974738Phase 1

A Trial of Belzutifan (PT2977, MK-6482) Tablets In Patients With Advanced Solid Tumors (MK-6482-001)

Active Not Recruiting
NCT07700758Phase 2

A Study of Belzutifan in Adolescent Participants With Solid Tumors (MK-9999-01E/LIGHTBEAM-U01)

Not Yet Recruiting
NCT07793942Phase 2

A Clinical Trial of MK-2010 Alone and With Other Treatments in Participants With Advanced Solid Tumors (MK-2010-002)

Not Yet Recruiting
NCT06428396Phase 2

Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)

Active Not Recruiting
NCT05468697Phase 1

A Study of Belzutifan (MK-6482) in Combination With Palbociclib Versus Belzutifan Monotherapy in Participants With Advanced Renal Cell Carcinoma (MK-6482-024/LITESPARK-024)

Active Not Recruiting
NCT05899049Phase 3

A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension Study

Active Not Recruiting
NCT07187778Phase 2

Phase II Trial of Single Agent Belzutifan or Pembrolizumab Versus Combination as Neoadjuvant Therapy in Clear Cell Renal Cell Carcinoma (BLAZE)

Recruiting
NCT07227402Phase 3

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Recruiting
NCT07179770Phase 1

Effects of Belzutifan on 89Zr-DFO-girentuximab PET Uptake in Patients With Renal Cell Carcinoma (RCC)

Recruiting
NCT07680205Phase 2

An Experimental Study of Belzutifan Impact on Catecholamine Metabolism

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
38