Success Metrics

Clinical Success Rate
85.0%

Based on 17 completed trials

Completion Rate
85%(17/20)
Active Trials
2(9%)
Results Posted
59%(10 trials)
Terminated
3(13%)

Phase Distribution

Ph phase_1
11
48%
Ph phase_2
11
48%
Ph not_applicable
1
4%

Phase Distribution

11

Early Stage

11

Mid Stage

0

Late Stage

Phase Distribution23 total trials
Phase 1Safety & dosage
11(47.8%)
Phase 2Efficacy & side effects
11(47.8%)
N/ANon-phased studies
1(4.3%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

85.0%

17 of 20 finished

Non-Completion Rate

15.0%

3 ended early

Currently Active

2

trials recruiting

Total Trials

23

all time

Status Distribution
Active(2)
Completed(17)
Terminated(3)
Other(1)

Detailed Status

Completed17
Terminated3
Active, not recruiting2
unknown1

Development Timeline

Analytics

Development Status

Total Trials
23
Active
2
Success Rate
85.0%
Most Advanced
Phase 2

Trials by Phase

Phase 111 (47.8%)
Phase 211 (47.8%)
N/A1 (4.3%)

Trials by Status

terminated313%
active_not_recruiting29%
completed1774%
unknown14%

Recent Activity

Clinical Trials (23)

Showing 20 of 23 trialsScroll for more
NCT01362803Phase 1

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

Active Not Recruiting
NCT00463814Phase 1

AZD6244 (ARRY-142886) Solid Oral Dosage Formulation in Participants With Advanced Solid Malignancies

Active Not Recruiting
NCT00600496Phase 1

A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)

Completed
NCT01306045Phase 2

Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies

Completed
NCT01160926Phase 1

Dual REctcal Angiogenesis or MEK Inhibition radioTHERAPY Trial

Terminated
NCT01146756Phase 1

MEK Inhibitor and Thoracic Radiotherapy Trial

Completed
NCT01248247Phase 2

BATTLE-2 Program: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer

Completed
NCT01134601Phase 1

A Phase I Study of AZD6244 in Combination With Capecitabine and Radiotherapy in Locally Advanced Adenocarcinoma of the Rectum

Terminated
NCT00780676Phase 2

Personalized Treatment Selection for Metastatic Breast Cancer

Terminated
NCT02583542Phase 1

A Study of AZD2014 in Combination With Selumetinib in Patients With Advanced Cancers

Unknown
NCT01287130Phase 1

AZD6244 With Cetuximab for Solid Tumors and Colorectal Cancer

Completed
NCT01021748Phase 1

A Combination Therapy Study of MK-2206 and AZD6244 in Participants With Advanced Solid Tumors (MK-2206-010)

Completed
NCT00890825Phase 2

AZD6244 in Combination With Docetaxel Versus Docetaxel Alone in KRAS Mutation Positive NSCLC Patients

Completed
NCT01229150Phase 2

Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With Erlotinib in KRAS Wild Type Advanced Non-Small Cell Lung Cancer (NSCLC) and a Randomized Phase II Study of AZD6244 With Erlotinib in Mutant KRAS Adva...

Completed
NCT00970359Not Applicable

Reacquisition of Radioactive Iodine (RAI) Uptake of RAI-Refractory Metastatic Thyroid Cancers by Pretreatment With the Selective MEK Inhibitor AZD6244

Completed
NCT01605916Phase 1

Investigate the Safety and Tolerability of AZD6244 Monotherapy or + Docetaxel in Japanese Patients With Advanced Solid Malignancies or Non-Small Cell Lung Cancer

Completed
NCT00936221Phase 2

Comparison of AZD6244 in Combination With Dacarbazine Versus (vs) Dacarbazine Alone in BRAF Mutation Positive Melanoma Patients

Completed
NCT00338130Phase 2

Randomised Study to Compare the Efficacy of AZD6244 vs TMZ

Completed
NCT00710515Phase 1

Study to Assess the Effect of Dosing AZD6244 HydSulfate in the Presence and Absence of Food in Patients With Advanced Solid Malignancies

Completed
NCT00372944Phase 2

AZD6244 vs. Capecitabine (Xeloda®) in Patients With Advanced or Metastatic Pancreatic Cancer, Who Have Failed First Line Gemcitabine Therapy

Completed

Drug Details

Intervention Type
DRUG
Total Trials
23