Success Metrics

Clinical Success Rate
84.2%

Based on 16 completed trials

Completion Rate
84%(16/19)
Active Trials
3(13%)
Results Posted
63%(10 trials)
Terminated
3(13%)

Phase Distribution

Ph phase_2
11
48%
Ph not_applicable
1
4%
Ph phase_1
11
48%

Phase Distribution

11

Early Stage

11

Mid Stage

0

Late Stage

Phase Distribution23 total trials
Phase 1Safety & dosage
11(47.8%)
Phase 2Efficacy & side effects
11(47.8%)
N/ANon-phased studies
1(4.3%)

Highest Phase Reached

Phase 2

Trial Status & Enrollment

Completion Rate

84.2%

16 of 19 finished

Non-Completion Rate

15.8%

3 ended early

Currently Active

3

trials recruiting

Total Trials

23

all time

Status Distribution
Active(3)
Completed(16)
Terminated(3)
Other(1)

Detailed Status

Completed16
Active, not recruiting3
Terminated3
unknown1

Development Timeline

Analytics

Development Status

Total Trials
23
Active
3
Success Rate
84.2%
Most Advanced
Phase 2

Trials by Phase

Phase 111 (47.8%)
Phase 211 (47.8%)
N/A1 (4.3%)

Trials by Status

active_not_recruiting313%
terminated313%
unknown14%
completed1670%

Recent Activity

Clinical Trials (23)

Showing 20 of 23 trialsScroll for more
NCT01362803Phase 1

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

Active Not Recruiting
NCT00463814Phase 1

AZD6244 (ARRY-142886) Solid Oral Dosage Formulation in Participants With Advanced Solid Malignancies

Active Not Recruiting
NCT00600496Phase 1

A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886)

Active Not Recruiting
NCT01306045Phase 2

Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer, Small Cell Lung Cancer, and Thymic Malignancies

Completed
NCT01160926Phase 1

Dual REctcal Angiogenesis or MEK Inhibition radioTHERAPY Trial

Terminated
NCT01146756Phase 1

MEK Inhibitor and Thoracic Radiotherapy Trial

Completed
NCT01248247Phase 2

BATTLE-2 Program: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer

Completed
NCT01134601Phase 1

A Phase I Study of AZD6244 in Combination With Capecitabine and Radiotherapy in Locally Advanced Adenocarcinoma of the Rectum

Terminated
NCT00780676Phase 2

Personalized Treatment Selection for Metastatic Breast Cancer

Terminated
NCT02583542Phase 1

A Study of AZD2014 in Combination With Selumetinib in Patients With Advanced Cancers

Unknown
NCT01287130Phase 1

AZD6244 With Cetuximab for Solid Tumors and Colorectal Cancer

Completed
NCT01021748Phase 1

A Combination Therapy Study of MK-2206 and AZD6244 in Participants With Advanced Solid Tumors (MK-2206-010)

Completed
NCT00890825Phase 2

AZD6244 in Combination With Docetaxel Versus Docetaxel Alone in KRAS Mutation Positive NSCLC Patients

Completed
NCT01229150Phase 2

Randomized Phase II Study of AZD6244 (Mitogen-activated Protein Kinase Inhibitor) MEK-Inhibitor With Erlotinib in KRAS Wild Type Advanced Non-Small Cell Lung Cancer (NSCLC) and a Randomized Phase II Study of AZD6244 With Erlotinib in Mutant KRAS Adva...

Completed
NCT00970359Not Applicable

Reacquisition of Radioactive Iodine (RAI) Uptake of RAI-Refractory Metastatic Thyroid Cancers by Pretreatment With the Selective MEK Inhibitor AZD6244

Completed
NCT01605916Phase 1

Investigate the Safety and Tolerability of AZD6244 Monotherapy or + Docetaxel in Japanese Patients With Advanced Solid Malignancies or Non-Small Cell Lung Cancer

Completed
NCT00936221Phase 2

Comparison of AZD6244 in Combination With Dacarbazine Versus (vs) Dacarbazine Alone in BRAF Mutation Positive Melanoma Patients

Completed
NCT00514761Phase 2

Phase II Efficacy Study of AZD6244 in Colorectal Cancer

Completed
NCT00372944Phase 2

AZD6244 vs. Capecitabine (Xeloda®) in Patients With Advanced or Metastatic Pancreatic Cancer, Who Have Failed First Line Gemcitabine Therapy

Completed
NCT00710515Phase 1

Study to Assess the Effect of Dosing AZD6244 HydSulfate in the Presence and Absence of Food in Patients With Advanced Solid Malignancies

Completed

Drug Details

Intervention Type
DRUG
Total Trials
23