Success Metrics

Clinical Success Rate
87.0%

Based on 20 completed trials

Completion Rate
87%(20/23)
Active Trials
3(9%)
Results Posted
25%(5 trials)
Terminated
3(9%)

Phase Distribution

Ph not_applicable
5
15%
Ph phase_3
2
6%
Ph early_phase_1
3
9%
Ph phase_4
10
30%
Ph phase_2
9
27%
Ph phase_1
3
9%

Phase Distribution

6

Early Stage

9

Mid Stage

12

Late Stage

Phase Distribution32 total trials
Early Phase 1First-in-human
3(9.4%)
Phase 1Safety & dosage
3(9.4%)
Phase 2Efficacy & side effects
9(28.1%)
Phase 3Large-scale testing
2(6.3%)
Phase 4Post-market surveillance
10(31.3%)
N/ANon-phased studies
5(15.6%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

83.3%

20 of 24 finished

Non-Completion Rate

16.7%

4 ended early

Currently Active

3

trials recruiting

Total Trials

33

all time

Status Distribution
Active(4)
Completed(20)
Terminated(4)
Other(5)

Detailed Status

Completed20
unknown5
Terminated3
Recruiting3
Not yet recruiting1
Withdrawn1

Development Timeline

Analytics

Development Status

Total Trials
33
Active
3
Success Rate
87.0%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (9.4%)
Phase 13 (9.4%)
Phase 29 (28.1%)
Phase 32 (6.3%)
Phase 410 (31.3%)
N/A5 (15.6%)

Trials by Status

not_yet_recruiting13%
withdrawn13%
unknown515%
completed2061%
terminated39%
recruiting39%

Recent Activity

3 active trials
Showing 5 of 33
not_yet_recruitingphase_2

ARX788 for Treating Patients With HER2-low Locally Advanced Unresectable or Metastatic Breast Cancer

NCT06224673
recruitingphase_2

Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura

NCT04063540
completed

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Amiloride vs Triamterene

NCT05125237
completedphase_4

Comparison of Optimal Hypertension Regimens

NCT02847338
recruitingphase_1

Mechanisms of Diuretic Resistance in Heart Failure, Aim 2

NCT05753059
View all 33 trials

Clinical Trials (33)

Showing 20 of 33 trialsScroll for more
NCT06224673Phase 2

ARX788 for Treating Patients With HER2-low Locally Advanced Unresectable or Metastatic Breast Cancer

Not Yet Recruiting
NCT04063540Phase 2

Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura

Recruiting
NCT05125237

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Amiloride vs Triamterene

Completed
NCT02847338Phase 4

Comparison of Optimal Hypertension Regimens

Completed
NCT05753059Phase 1

Mechanisms of Diuretic Resistance in Heart Failure, Aim 2

Recruiting
NCT06923709Phase 2

Beneficial Effect of Amiloride on Progression of Chronic Kidney Disease

Recruiting
NCT05079789Phase 3

Amiloride in Nephrotic Syndrome

Terminated
NCT04331691Phase 4

Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension

Completed
NCT06416735Phase 3

Natriuretic Effect of Amiloride in Relation to the Alpha Adducin Gene (ADD-AMI) RS4961 Variant

Completed
NCT02525796Phase 2

Evaluating Alternative Medical Therapies in Primary Hyperparathyroidism

Completed
NCT04181008Early Phase 1

Pharmacokinetics of Amiloride Nasal Spray in Healthy Volunteers

Completed
NCT02497300Phase 2

Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney Disease

Completed
NCT03170336Phase 4

A New Application of Amiloride in the Treatment of Patient With Chronic Kidney Disease In Reducing Urinary PROtein

Completed
NCT01910259Phase 2

MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial

Completed
NCT02522650Phase 4

A Crossover Pilot Study of the Effect of Amiloride on Proteinuria

Unknown
NCT01246180Not Applicable

Microcirculation & ASICs

Completed
NCT02832973Phase 4

Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension

Completed
NCT01733680Early Phase 1

Amiloride Hydrochloride as an Effective Treatment for ADHD

Terminated
NCT01802489Phase 2

Amiloride Clinical Trial In Optic Neuritis

Completed
NCT01804777Early Phase 1

Epithelial Sodium Channel (ENaC) as a Novel Mechanism for Hypertension and Volume Expansion in Type 2 Diabetes

Terminated

Drug Details

Intervention Type
DRUG
Total Trials
33