Success Metrics

Clinical Success Rate
100.0%

Based on 5 completed trials

Completion Rate
100%(5/5)
Active Trials
7(54%)
Results Posted
60%(3 trials)

Phase Distribution

Ph phase_2
3
23%
Ph phase_3
3
23%
Ph phase_1
7
54%

Phase Distribution

7

Early Stage

3

Mid Stage

3

Late Stage

Phase Distribution13 total trials
Phase 1Safety & dosage
7(53.8%)
Phase 2Efficacy & side effects
3(23.1%)
Phase 3Large-scale testing
3(23.1%)

Highest Phase Reached

Phase 3

Trial Status & Enrollment

Completion Rate

83.3%

5 of 6 finished

Non-Completion Rate

16.7%

1 ended early

Currently Active

7

trials recruiting

Total Trials

13

all time

Status Distribution
Active(7)
Completed(5)
Terminated(1)

Detailed Status

Active, not recruiting6
Completed5
Withdrawn1
Recruiting1

Development Timeline

Analytics

Development Status

Total Trials
13
Active
7
Success Rate
100.0%
Most Advanced
Phase 3

Trials by Phase

Phase 17 (53.8%)
Phase 23 (23.1%)
Phase 33 (23.1%)

Trials by Status

withdrawn18%
recruiting18%
active_not_recruiting646%
completed538%

Recent Activity

Clinical Trials (13)

Showing 13 of 13 trials
NCT04278781Phase 2

AG-120 in People With IDH1 Mutant Chondrosarcoma

Active Not Recruiting
NCT02677922Phase 1

A Study to Assess the Safety and Efficacy of Two Combinations of Isocitrate Dehydrogenase (IDH) Mutant Targeted Therapies Plus Azacitidine in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) Harboring IDH Mutations Who Are Not Candidates to Receive Intensive Induction Chemotherapy

Active Not Recruiting
NCT03343197Phase 1

Study of AG-120 and AG-881 in Subjects With Low Grade Glioma

Completed
NCT02073994Phase 1

Study of Orally Administered AG-120 in Subjects With Advanced Solid Tumors, Including Glioma, With an IDH1 Mutation

Completed
NCT03173248Phase 3

Study of AG-120 (Ivosidenib) vs. Placebo in Combination With Azacitidine in Participants With Previously Untreated Acute Myeloid Leukemia With an IDH1 Mutation

Active Not Recruiting
NCT02074839Phase 1

Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

Recruiting
NCT03503409Phase 2

IDH1 (AG 120) Inhibitor in Patients With IDH1 Mutated Myelodysplastic Syndrome

Active Not Recruiting
NCT02632708Phase 1

Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 Mutation

Active Not Recruiting
NCT03839771Phase 3

A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy

Active Not Recruiting
NCT02989857Phase 3

Study of AG-120 in Previously Treated Advanced Cholangiocarcinoma With IDH1 Mutations (ClarIDHy)

Completed
NCT04044209Phase 2

A Study of the IDH1 Inhibitor AG-120 in Combination With the Checkpoint Blockade Inhibitor, Nivolumab, for Patients With IDH1 Mutated Relapsed/Refractory AML and High Risk MDS

Withdrawn
NCT02831972Phase 1

Drug-Drug Interaction Study of AG120 in Healthy Subjects

Completed
NCT02579707Phase 1

Food Effect Study of AG120 in Healthy Subjects

Completed

All 13 trials loaded

Drug Details

Intervention Type
DRUG
Total Trials
13