Key Insights

Highlights

Success Rate

63% trial completion

Published Results

15 trials with published results (27%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

16.4%

9 terminated out of 55 trials

Success Rate

62.5%

-24.0% vs benchmark

Late-Stage Pipeline

5%

3 trials in Phase 3/4

Results Transparency

100%

15 of 15 completed with results

Key Signals

15 with results63% success

Data Visualizations

Phase Distribution

50Total
Not Applicable (3)
Early P 1 (2)
P 1 (26)
P 2 (16)
P 3 (3)

Trial Status

Completed15
Recruiting10
Terminated9
Active Not Recruiting8
Unknown7
Not Yet Recruiting3

Trial Success Rate

62.5%

Benchmark: 86.5%

Based on 15 completed trials

Clinical Trials (55)

Showing 20 of 20 trials
NCT06083883Phase 1RecruitingPrimary

Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1

NCT02180867Phase 2Active Not Recruiting

Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

NCT06625190Phase 1Recruiting

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

NCT04420975Phase 1Active Not Recruiting

Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

NCT04008238Not ApplicableCompleted

Prospective Identification of Predictive Biomarkers of Trabectedin Efficacy in Non-L Soft-tissue Sarcoma Patients

NCT03016819Phase 3Recruiting

Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS)

NCT06617572UnknownPrimary

Expanded Access Protocol (EAP) for Nonconforming (NC) Afami-cel

NCT05642455Phase 1RecruitingPrimary

SPEARHEAD-3 Pediatric Study

NCT04044768Phase 2Active Not RecruitingPrimary

Spearhead 1 Study in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma

NCT04995003Phase 1Recruiting

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

NCT06946225Phase 1Recruiting

ACTengine® IMA203 Combined With mRNA-4203

NCT02869217Phase 1Active Not Recruiting

Study of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid Tumors

NCT07261657Early Phase 1Not Yet Recruiting

N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy

NCT03618381Phase 1Active Not Recruiting

EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

NCT04483778Phase 1Active Not Recruiting

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

NCT02875548Phase 1Completed

A Study to Assess Long-term Safety of Tazemetostat in Adult Participants of All Ages With Any Disease Treated With Tazemetostat in a Previous Clinical Study

NCT05492682Phase 1Active Not Recruiting

START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer

NCT06277154Phase 2Recruiting

MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma

NCT02601950Phase 2Completed

A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma

NCT05910307RecruitingPrimary

Synovial Sarcoma Registry / Biospecimen Repository

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