Key Insights

Highlights

Success Rate

54% trial completion

Published Results

12 trials with published results (23%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 60/100

Termination Rate

11.3%

6 terminated out of 53 trials

Success Rate

53.8%

-32.7% vs benchmark

Late-Stage Pipeline

9%

5 trials in Phase 3/4

Results Transparency

171%

12 of 7 completed with results

Key Signals

12 with results54% success

Data Visualizations

Phase Distribution

51Total
Not Applicable (2)
P 1 (16)
P 2 (28)
P 3 (4)
P 4 (1)

Trial Status

Recruiting22
Active Not Recruiting13
Completed7
Terminated6
Withdrawn3
Not Yet Recruiting1

Trial Success Rate

53.8%

Benchmark: 86.6%

Based on 7 completed trials

Clinical Trials (53)

Showing 20 of 20 trials
NCT06788990Phase 2Recruiting

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

NCT06265285Phase 2Recruiting

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

NCT06589804Phase 3Recruiting

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

NCT05063552Phase 2Active Not Recruiting

Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers

NCT06980038Phase 2Recruiting

Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

NCT04671667Phase 2RecruitingPrimary

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

NCT05172258Phase 2Active Not Recruiting

Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck

NCT07026474Phase 3RecruitingPrimary

Re-Radiochemotherapy and Pembrolizumab vs. Immuno(Chemo)Therapy for Locoregionally Recurrent PD-L1 Positive (CPS≥1) HNSCC

NCT07807163Phase 2Recruiting

A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCC

NCT07156227Phase 1Recruiting

Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma

NCT04576091Phase 1Active Not Recruiting

Testing the Addition of an Anti-cancer Drug, BAY 1895344, With Radiation Therapy to the Usual Pembrolizumab Treatment for Recurrent Head and Neck Cancer

NCT06239220Phase 2Recruiting

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

NCT02955290Phase 1Active Not Recruiting

CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer

NCT07751289Phase 2Not Yet RecruitingPrimary

Anti-PD-1 Therapy in Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma

NCT04290546Phase 1Completed

CIML NK Cell in Head & Neck Cancer

NCT01468896Phase 1Active Not Recruiting

Cetuximab and Recombinant Interleukin-12 in Treating Patients With Squamous Cell Carcinoma of the Head and Neck That is Recurrent, Metastatic, or Cannot Be Removed by Surgery

NCT04375384Phase 2Recruiting

Cetuximab After Immunotherapy for the Treatment of Head and Neck Squamous Cell Cancer

NCT06662058Not ApplicableRecruiting

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

NCT07213934Phase 1Recruiting

Phase I/ II Trial Combining PD-1 Inhibition and Neoadjuvant Proton or Photon Radiation Therapy in Recurrent Head and Neck Squamous Cell Carcinoma

NCT04862650Phase 2Active Not Recruiting

Cemiplimab, Low-Dose Paclitaxel and Carboplatin for the Treatment of Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

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