Primary Central Nervous System Lymphoma
66
21
28
12
Key Insights
Highlights
Success Rate
86% trial completion
Clinical Risk Assessment
Based on trial outcomes
High Risk
Score: 62/100
3.0%
2 terminated out of 66 trials
85.7%
-0.8% vs benchmark
8%
5 trials in Phase 3/4
33%
4 of 12 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 12 completed trials
Clinical Trials (66)
A Study of Epcoritamab and Ibrutinib in People With Central Nervous System Lymphoma (CNSL)
Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib,Rituximab (TEDDI-R) in Primary CNS Lymphoma
OptiMATe: De-escalated Induction Treatment in Primary CNS Lymphoma
Acalabrutinib and Durvalumab in Primary and Secondary Central Nervous System Lymphoma
A Multicenter Two-Cohort Study of Methotrexate, Rituximab, Sintilimab and Pirtobrutinib for Treatment-Naive PCNSL vs. Real-World Investigator-Selected Treatment (Observational Cohort)
Zanubrutinib With Pemetrexed to Treat Relapsed/Refractory Primary and Secondary Central Nervous System (CNS) Lymphomas
Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL
Pembrolizumab, Ibrutinib and Rituximab in PCNSL
Methotrexate Early Toxicity Monitoring
Glofitamab With Obinutuzumab Pre-treatment for the Treatment of Central Nervous System Lymphoma
Q702 for the Treatment of Patients With Hematologic Malignancies
A Study of GNC-038, a Tetra-specific Antibody, in Patients With Central Nervous System Lymphoma (PCNSL) and Relapsed or Refractory Secondary Central Nervous System Lymphoma (SCNSL)
Orelabrutinib Combined With Teniposide, Rituximab and Methotrexate for Newly Diagnosed PCNSL
New-diagnosed PCNSL Treated With Methotrexate (MTX) and Orelabrutinib-based Regimen
[18F]-Fludarabine PET/MRI in Primary Central Nervous System Lymphoma
Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSL
Maintenance Obinutuzumab in Treating Patients With Central Nervous System Lymphoma Who Have Achieved a Complete or Partial Response
Phase I Study Evaluating Tolerability, Safety, Pharmacokinetics, and Efficacy of Combined ONO-4059 and R-MPV Therapy for PCNSL
Tirabrutinib Maintenance Versus Placebo in Patients With Primary CNS Lymphoma in Complete Remission (JCOG2104)
Rituximab, Lenalidomide Combined With Methotrexate and Temozolomide For Primary Central Nervous System Lymphoma