Key Insights

Highlights

Success Rate

86% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 62/100

Termination Rate

3.0%

2 terminated out of 66 trials

Success Rate

85.7%

-0.8% vs benchmark

Late-Stage Pipeline

8%

5 trials in Phase 3/4

Results Transparency

33%

4 of 12 completed with results

Key Signals

4 with results86% success

Data Visualizations

Phase Distribution

64Total
Not Applicable (6)
P 1 (18)
P 2 (35)
P 3 (4)
P 4 (1)

Trial Status

Recruiting21
Unknown18
Completed12
Active Not Recruiting7
Withdrawn3
Not Yet Recruiting3

Trial Success Rate

85.7%

Benchmark: 86.5%

Based on 12 completed trials

Clinical Trials (66)

Showing 20 of 20 trials
NCT07082868Phase 1Recruiting

A Study of Epcoritamab and Ibrutinib in People With Central Nervous System Lymphoma (CNSL)

NCT02203526Phase 1Active Not RecruitingPrimary

Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib,Rituximab (TEDDI-R) in Primary CNS Lymphoma

NCT04931368Phase 3Active Not RecruitingPrimary

OptiMATe: De-escalated Induction Treatment in Primary CNS Lymphoma

NCT04462328Phase 1Active Not RecruitingPrimary

Acalabrutinib and Durvalumab in Primary and Secondary Central Nervous System Lymphoma

NCT07350850Phase 2Recruiting

A Multicenter Two-Cohort Study of Methotrexate, Rituximab, Sintilimab and Pirtobrutinib for Treatment-Naive PCNSL vs. Real-World Investigator-Selected Treatment (Observational Cohort)

NCT05681195Phase 2RecruitingPrimary

Zanubrutinib With Pemetrexed to Treat Relapsed/Refractory Primary and Secondary Central Nervous System (CNS) Lymphomas

NCT06475235Phase 1Recruiting

Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL

NCT04421560Phase 1RecruitingPrimary

Pembrolizumab, Ibrutinib and Rituximab in PCNSL

NCT07406230Not ApplicableNot Yet RecruitingPrimary

Methotrexate Early Toxicity Monitoring

NCT06922604Phase 1RecruitingPrimary

Glofitamab With Obinutuzumab Pre-treatment for the Treatment of Central Nervous System Lymphoma

NCT06712810Phase 1Recruiting

Q702 for the Treatment of Patients With Hematologic Malignancies

NCT05485753Phase 1Active Not RecruitingPrimary

A Study of GNC-038, a Tetra-specific Antibody, in Patients With Central Nervous System Lymphoma (PCNSL) and Relapsed or Refractory Secondary Central Nervous System Lymphoma (SCNSL)

NCT07185373Phase 2Not Yet RecruitingPrimary

Orelabrutinib Combined With Teniposide, Rituximab and Methotrexate for Newly Diagnosed PCNSL

NCT06115824CompletedPrimary

New-diagnosed PCNSL Treated With Methotrexate (MTX) and Orelabrutinib-based Regimen

NCT05390814Phase 1CompletedPrimary

[18F]-Fludarabine PET/MRI in Primary Central Nervous System Lymphoma

NCT04906096Phase 2RecruitingPrimary

Paxalisib (GDC-0084) In Recurrent Or Refractory PCNSL

NCT06175000Phase 2RecruitingPrimary

Maintenance Obinutuzumab in Treating Patients With Central Nervous System Lymphoma Who Have Achieved a Complete or Partial Response

NCT06541665Phase 1Active Not RecruitingPrimary

Phase I Study Evaluating Tolerability, Safety, Pharmacokinetics, and Efficacy of Combined ONO-4059 and R-MPV Therapy for PCNSL

NCT06940791Phase 2RecruitingPrimary

Tirabrutinib Maintenance Versus Placebo in Patients With Primary CNS Lymphoma in Complete Remission (JCOG2104)

NCT04737889Phase 2RecruitingPrimary

Rituximab, Lenalidomide Combined With Methotrexate and Temozolomide For Primary Central Nervous System Lymphoma

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