Key Insights

Highlights

Success Rate

83% trial completion

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 49/100

Termination Rate

11.1%

2 terminated out of 18 trials

Success Rate

83.3%

-3.2% vs benchmark

Late-Stage Pipeline

22%

4 trials in Phase 3/4

Results Transparency

50%

5 of 10 completed with results

Key Signals

5 with results83% success

Data Visualizations

Phase Distribution

11Total
P 1 (3)
P 2 (4)
P 3 (4)

Trial Status

Completed10
Active Not Recruiting3
Terminated2
Unknown2
Recruiting1

Trial Success Rate

83.3%

Benchmark: 86.5%

Based on 10 completed trials

Clinical Trials (18)

Showing 18 of 18 trials
NCT05982938Unknown

Danicopan Early Access Program

NCT07413250Active Not Recruiting

Assess Long-Term Safety of Danicopan Add-on Therapy in Participants With Paroxysmal Nocturnal Hemoglobinuria: Analysis of IPIG-Registry Data

NCT07413679Active Not Recruiting

Long-term Safety of Danicopan: IPIG Registry-based Cohort Study

NCT06578949Phase 3Completed

Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Ravulizumab in Chinese Adults Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

NCT06449001Phase 3Recruiting

Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With PNH Who Have Clinically Significant Extravascular Hemolysis

NCT06799546Phase 3CompletedPrimary

A Phase III Study to Evaluate the Efficacy and Safety of HSK39297 in Patients With Paroxysmal Nocturnal Hemoglobinuria Who Are Naive to Complement Inhibitor Therapy

NCT04702568Phase 2Terminated

A Long-Term Safety Study of BCX9930 in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

NCT03531255Phase 3Active Not RecruitingPrimary

Pegcetacoplan Long Term Safety and Efficacy Extension Study

NCT05337683CompletedPrimary

A Retrospective Non-Interventional Study to Evaluate the Impact of Eculizumab in Korean PNH Patients

NCT03460301CompletedPrimary

Observational of PNH Type Cells in Korean Patients With Bone Marrow Failure Syndrome and Having Hemolytic PNH

NCT04725812Phase 2Terminated

Complement Regulation to Undo Systemic Harm in Preeclampsia

NCT05884060CompletedPrimary

Retrospective Chart Review Screening Algorithm to Assess the Prevalence of PNH-clones

NCT02605993Phase 2Completed

Open-label, Multiple Ascending Dose Study of Ravulizumab (ALXN1210) in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

NCT05539248Phase 1UnknownPrimary

A Study on the Safety, Tolerability, Efficacy, Pharmacokinetics and Pharmacodynamics of CAN106 in Subjects With PNH

NCT05095168Phase 1CompletedPrimary

Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of a Single Ascending Dose (SAD) of CAN106 Administered Intravenously (IV) in Healthy Subjects

NCT02598583Phase 1CompletedPrimary

Dose-Escalation Study of ALXN1210 IV in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

NCT03593200Phase 2CompletedPrimary

A Phase IIa Study to Assess the Safety, Efficacy, and Pharmacokinetics of Subcutaneously Administered Pegcetacoplan (APL-2) in Subjects With PNH

NCT01412047Completed

Paroxysmal Nocturnal Hemoglobinuria Human Anti-Human Antibodies Study

Showing all 18 trials

Research Network

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