Key Insights

Highlights

Success Rate

57% trial completion

Published Results

14 trials with published results (18%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 77/100

Termination Rate

21.3%

17 terminated out of 80 trials

Success Rate

57.5%

-29.0% vs benchmark

Late-Stage Pipeline

19%

15 trials in Phase 3/4

Results Transparency

61%

14 of 23 completed with results

Key Signals

14 with results57% success17 terminated

Data Visualizations

Phase Distribution

70Total
Not Applicable (8)
Early P 1 (1)
P 1 (16)
P 2 (30)
P 3 (10)
P 4 (5)

Trial Status

Completed23
Terminated17
Unknown16
Active Not Recruiting11
Recruiting9
Suspended2

Trial Success Rate

57.5%

Benchmark: 86.5%

Based on 23 completed trials

Clinical Trials (80)

Showing 20 of 20 trials
NCT05407155Not ApplicableActive Not RecruitingPrimary

Bevacizumab Plus Nab-paclitaxel and Platinum for Immunotherapy-treated Non-squamous Non-small Cell Lung Cancer

NCT07144280Phase 3Recruiting

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

NCT06812871Phase 2CompletedPrimary

High-dose Furmonertinib Combined With Bevacizumab and Intrathecal Pemetrexed Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Meningeal Metastasis

NCT05689671Phase 4Active Not RecruitingPrimary

Pemetrexed-free vs. Pemetrexed-based Immunochemotherapy in Metastatic TTF-1 Negative Lung Adenocarcinoma

NCT04563338Phase 2Active Not Recruiting

An Exploratory Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma and Non-Small Cell Lung Cancer With Liver Metastases (INTEGRATE)

NCT06106802Phase 2RecruitingPrimary

Lazertinib & Tepotinib for EGFR Mutant NSCLC in MET Overexpressed or Amplified Who Progressed After Lazertinib Treatment

NCT04868877Phase 1Active Not RecruitingPrimary

Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination

NCT03611738Phase 1Active Not Recruiting

Ceritinib Plus Docetaxel in ALK-Negative, EGFR WT Advanced NSCLC

NCT07250477Phase 2Recruiting

Risk-adapted, Proteomic-guided Systemic Therapy for Previously Untreated Advanced Non-small Cell Lung Cancer

NCT04619004Phase 2Active Not RecruitingPrimary

HERTHENA-Lung01: Patritumab Deruxtecan in Subjects With Metastatic or Locally Advanced EGFR-mutated Non-Small Cell Lung Cancer

NCT07292168Phase 1Recruiting

A Phase 1b/2 Study of the Safety and Efficacy of the Monoclonal Antibody OM-RCA-01 in Patients With Metastatic Tumors Expressing Fibroblast Growth Factor Receptor 1

NCT05889247Not ApplicableRecruitingPrimary

Circulating Tumor DNA Guided Treatment Monitoring in Advanced Lung Cancer

NCT02314364Phase 2CompletedPrimary

A Trial of Integrating SBRT With Targeted Therapy in Stage IV Oncogene-driven NSCLC

NCT04163432Phase 2Active Not RecruitingPrimary

Staggered, Chemo-Immunotherapy With Durvalumab, MEDI4736 Pemetrexed & Carboplatin (PC) for Metastatic Non-Squamous NSCLC

NCT03469960Phase 3CompletedPrimary

Double Immune Checkpoint Inhibitors in PD-L1-positive Stage IV Non-small Lung CancEr

NCT02812667Phase 1CompletedPrimary

Nivolumab in Combination With Plinabulin in Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC)

NCT04504071Phase 2Active Not RecruitingPrimary

Dacomitinib in Lung Cancer With Uncommon EGFR Mutations

NCT04154956Phase 3Active Not RecruitingPrimary

SAR408701 Versus Docetaxel in Previously Treated, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Positive Metastatic Non-squamous Non-small-cell Lung Cancer Patients

NCT04394624Phase 2TerminatedPrimary

Tusamitamab Ravtansine (SAR408701) in Combination With Ramucirumab or Ramucirumab and Pembrolizumab in Pretreated Patients With NSQ NSCLC (CARMEN-LC04)

NCT03732274Phase 1CompletedPrimary

Phase 1b/2a, Open-label Study of Vactosertib in Combination With Durvalumab in Advanced NSCLC

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