Key Insights

Highlights

Success Rate

50% trial completion

Treatment Research

11 treatments under study, led by Rgn259

Research Leaders

10 sponsors active, led by ReGenTree, LLC

Related Conditions

Often studied with 14 related conditions

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 40/100

Termination Rate

18.2%

2 terminated out of 11 trials

Success Rate

50.0%

-36.6% vs benchmark

Late-Stage Pipeline

45%

5 trials in Phase 3/4

Results Transparency

150%

3 of 2 completed with results

Key Signals

3 with results50% success

Data Visualizations

Phase Distribution

8Total
Not Applicable (1)
Phase 1/2 (1)
Phase 2 (1)
Phase 3 (3)
Phase 4 (2)

Trial Status

Unknown3
Completed2
Recruiting2
Terminated2
Not Yet Recruiting1
Withdrawn1

Trial Success Rate

50.0%

Benchmark: 86.6%

Based on 2 completed trials

Clinical Trials (11)

Showing 11 of 11 trials
NCT07694817Not Yet RecruitingPrimary

Clinical Predictors of Visual Outcome in Patients Affected With Ocular Surface Diseases

NCT04604834Not ApplicableRecruitingPrimary

Autologous Platelet-rich Plasma (APRP) in the Treatment of Neurotrophic Keratopathy

NCT05555589Phase 3RecruitingPrimary

Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

NCT06411145Phase 4Withdrawn

Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis

NCT06412718Unknown

Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies

NCT04957758Phase 2CompletedPrimary

Phase 2 Clinical Trial to Evaluate OC-01 Nasal Spray in Subjects With Neurotrophic Keratopathy

NCT06331910Phase 4UnknownPrimary

Efficacy and Safety of Topical Insulin for Neurotrophic Corneal Ulcers

NCT02600429Phase 3TerminatedPrimary

Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1

NCT03084861Phase 1/2TerminatedPrimary

A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy

NCT04293549CompletedPrimary

An 8-week Follow-up to Evaluate the Renewal of Corneal Nerves Structure and Function in Patients With Neurotrophic Keratopathy Treated With Recombinant Human Nerve Growth Factor (rhNGF) Eyedrops

SYF110fb62d03d34d2ab698859132c6be3bPhase 3Unknown

SEER-3: A Phase 3, Multi-Center, Randomized, Parallel, Double Masked, Placebo-Controlled Clinical Study to Assess the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of Neurotrophic Keratopathy

Showing all 11 trials

Research Network

Common Treatments

  • Rgn2592
  • Aprp First1
  • Cenegermin Recombinant Human Nerve Growth Factor Rhngf Eyedrops1
  • Oc01 Varenicline Nasal Spray 12 Mgml1
  • Pfat First1

Active Sponsors

  • ReGenTree, LLC2
  • Banc de Sang i Teixits1
  • Universidad Autonoma de Nuevo Leon1
  • IRCCS Ospedale San Raffaele1
  • Oyster Point Pharma, Inc.1

Top Investigators

Related Conditions

  • Limbal Stem Cell Deficiency1
  • Cornea Inflamed1
  • Eec Syndrome1
  • Aniridia1
  • Exposure Keratopathy1

Activity Timeline