Neurotrophic Keratopathy
11
2
2
2
Key Insights
Highlights
Success Rate
50% trial completion
Treatment Research
11 treatments under study, led by Rgn259
Research Leaders
10 sponsors active, led by ReGenTree, LLC
Related Conditions
Often studied with 14 related conditions
Clinical Risk Assessment
Based on trial outcomes
Moderate Risk
Score: 40/100
18.2%
2 terminated out of 11 trials
50.0%
-36.6% vs benchmark
45%
5 trials in Phase 3/4
150%
3 of 2 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.6%
Based on 2 completed trials
Clinical Trials (11)
Clinical Predictors of Visual Outcome in Patients Affected With Ocular Surface Diseases
Autologous Platelet-rich Plasma (APRP) in the Treatment of Neurotrophic Keratopathy
Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2
Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis
Validation of Human Drugs Target of Repurposed Drugs and Novel Therapies
Phase 2 Clinical Trial to Evaluate OC-01 Nasal Spray in Subjects With Neurotrophic Keratopathy
Efficacy and Safety of Topical Insulin for Neurotrophic Corneal Ulcers
Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1
A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy
An 8-week Follow-up to Evaluate the Renewal of Corneal Nerves Structure and Function in Patients With Neurotrophic Keratopathy Treated With Recombinant Human Nerve Growth Factor (rhNGF) Eyedrops
SEER-3: A Phase 3, Multi-Center, Randomized, Parallel, Double Masked, Placebo-Controlled Clinical Study to Assess the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of Neurotrophic Keratopathy
Research Network
Common Treatments
- Rgn2592
- Aprp First1
- Cenegermin Recombinant Human Nerve Growth Factor Rhngf Eyedrops1
- Oc01 Varenicline Nasal Spray 12 Mgml1
- Pfat First1
Active Sponsors
- ReGenTree, LLC2
- Banc de Sang i Teixits1
- Universidad Autonoma de Nuevo Leon1
- IRCCS Ospedale San Raffaele1
- Oyster Point Pharma, Inc.1
Top Investigators
Hospital Universitario Dr. Jose E. Gonzalez
Ophtalmology Clinic, G. d'Annunzio University
SightMD, New York, New York
Banc de Sang i Teixits
Related Conditions
- Limbal Stem Cell Deficiency1
- Cornea Inflamed1
- Eec Syndrome1
- Aniridia1
- Exposure Keratopathy1