Key Insights

Highlights

Success Rate

77% trial completion

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 49/100

Termination Rate

11.5%

3 terminated out of 26 trials

Success Rate

76.9%

-9.6% vs benchmark

Late-Stage Pipeline

19%

5 trials in Phase 3/4

Results Transparency

50%

5 of 10 completed with results

Key Signals

5 with results77% success

Data Visualizations

Phase Distribution

19Total
Not Applicable (4)
P 1 (4)
P 2 (6)
P 4 (5)

Trial Status

Completed10
Recruiting6
Terminated3
Withdrawn3
Not Yet Recruiting1
Suspended1

Trial Success Rate

76.9%

Benchmark: 86.5%

Based on 10 completed trials

Clinical Trials (26)

Showing 20 of 20 trials
NCT07568730Phase 2RecruitingPrimary

A Multicenter, Randomized, Vehicle-Controlled, Double-Masked to Open-Label Study to Evaluate the Safety and Efficacy of Lacripep 4 μM Ophthalmic Solution in Subjects With Neurotrophic Keratitis

NCT06597422Phase 1CompletedPrimary

A Study of STSP-0902 Ophthalmic Solution in Healthy Subjects

NCT06999733Phase 1RecruitingPrimary

A Study Comparing KB801 Verse Placebo in Patients With Stage 2 or 3 Neurotrophic Keratitis

NCT05758753Not ApplicableSuspended

QST for Corneal Nerve Function

NCT05552261CompletedPrimary

DEFENDO Long Term Follow-up Study in Stage 1 NK Patients

NCT04485546Phase 4CompletedPrimary

Study to Evaluate OXERVATE® in Patients With Stage 1 Neurotrophic Keratitis

NCT07073729Not ApplicableNot Yet RecruitingPrimary

Corneal Neurotization vs. Cenergermin for Neurotrophic Keratitis: A Pilot Study

NCT06975748Phase 2RecruitingPrimary

A Phase II Study of STSP-0902 Ophthalmic Solution in Patients With Neurotrophic Keratitis

NCT04276558Phase 2CompletedPrimary

REC 0/0559 Eye Drops for Treatment of Moderate and Severe Neurotrophic Keratitis in Adult Patients

NCT06964269Phase 4Recruiting

Use of Acthar Gel Single-Dose Pre-Filled SelfJectTM Injector in Patients With Moderate-Severe Keratitis and Autoimmune Disease

NCT06947850Phase 4Active Not Recruiting

DOMPE -MT Neurotrophic Keratitis

NCT04627571CompletedPrimary

Corneal Nerves After Treatment With Cenegermin

NCT02707120Phase 4WithdrawnPrimary

Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis

NCT06364657Terminated

Differences in Corneal Structure and Function in Patients With Sjogrens vs. Non-Sjogrens Dry Eye

NCT06411145Phase 4WithdrawnPrimary

Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis

NCT05927428Phase 2RecruitingPrimary

Assessment of the Initial Efficacy and Safety of BRM424 Ophthalmic Solutions in Patients With Neurotrophic Keratitis

NCT04909450Phase 1CompletedPrimary

Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Neurotrophic Keratitis Subjects

NCT01756456Phase 1CompletedPrimary

Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis.

NCT04573647Recruiting

OCT Evaluation of Neurotrophic Ulcer Following Treatment With Oxervate

NCT05321251Phase 2WithdrawnPrimary

Topical Insulin Drops for the Treatment of Neurotrophic Keratopathy.

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