Hypophosphatasia (HPP)
10
2
3
6
Key Insights
Highlights
Success Rate
100% trial completion (above average)
Treatment Research
5 treatments under study, led by Asfotase Alfa
Research Leaders
6 sponsors active, led by Alexion Pharmaceuticals, Inc.
Clinical Risk Assessment
Based on trial outcomes
Low Risk
Score: 25/100
0.0%
0 terminated out of 10 trials
100.0%
+13.4% vs benchmark
0%
0 trials in Phase 3/4
83%
5 of 6 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.6%
Based on 6 completed trials
Clinical Trials (10)
Clarify HPP: Disease Burden of HPP Patients in China
Registry of Patients With Hypophosphatasia
A Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALE1 in Healthy Adults and Adults With Hypophosphatasia in Order to Identify Suitable Doses of ALE1
Evaluation of Bone Architecture and Bone Strength in Adults With Hypophosphatasia (HPP)
Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP)
Safety and Efficacy of Asfotase Alfa in Juvenile Patients With Hypophosphatasia (HPP)
A Retrospective Study of the Natural History of Patients With Severe Perinatal and Infantile Hypophosphatasia (HPP)
Retrospective, Non-interventional Natural History of Patients With Juvenile-onset Hypophosphatasia (HPP)
Safety Study of Human Recombinant Tissue Non-Specific Alkaline Phosphatase Fusion Protein Asfotase Alfa in Adults With Hypophosphatasia (HPP)
Extension Study of Protocol ENB-006-09 - Study of Asfotase Alfa in Children With Hypophosphatasia (HPP)
Research Network
Common Treatments
- Asfotase Alfa4
- Microindentation1
- High Resolution Peripheral Quantitative Computed Tomography Hrpqct1
- Ale11
- Biochemical Analysis Of Different Bone Markers1
Active Sponsors
- Alexion Pharmaceuticals, Inc.7
- Alesta Therapeutics1
- Odense University Hospital1
- AstraZeneca1
- Hvidovre University Hospital1
Top Investigators
Peking Union Medical College Hospital
Related Conditions
- Hypophosphatasia1