Key Insights

Highlights

Success Rate

80% trial completion

Clinical Risk Assessment

Based on trial outcomes

Low Risk

Score: 27/100

Termination Rate

11.5%

3 terminated out of 26 trials

Success Rate

80.0%

-6.5% vs benchmark

Late-Stage Pipeline

31%

8 trials in Phase 3/4

Results Transparency

67%

8 of 12 completed with results

Key Signals

8 with results80% success

Data Visualizations

Phase Distribution

23Total
Not Applicable (3)
P 1 (1)
P 2 (11)
P 3 (7)
P 4 (1)

Trial Status

Completed12
Recruiting5
Unknown4
Terminated3
Active Not Recruiting2

Trial Success Rate

80.0%

Benchmark: 86.5%

Based on 12 completed trials

Clinical Trials (26)

Showing 20 of 20 trials
NCT00091871Recruiting

A Longitudinal Study of Familial Hypereosinophilia (FE): Natural History and Markers of Disease Progression

NCT06477653Phase 2RecruitingPrimary

Dupilumab as Add-On Therapy for Hypereosinophilic Syndrome With Partial Clinical Response to Eosinophil-Depleting Biologic Agents

NCT04965636Phase 3CompletedPrimary

Study in Pediatrics With HypEREosinophilic Syndrome (SPHERE)

NCT04191304Phase 3Active Not RecruitingPrimary

A Phase III Study to Evaluate the Efficacy and Safety of Benralizumab in Patients With Hypereosinophilic Syndrome (HES)

NCT00044304Phase 2Active Not Recruiting

Tyrosine Kinase Inhibition to Treat Myeloid Hypereosinophilic Syndrome

NCT04018118Recruiting

Natural History of Hypereosinophilia and Hypereosinophilic Syndromes

NCT01713504Not ApplicableCompletedPrimary

Identification of New Markers in the Hypereosinophilic Syndrome

NCT00255346Phase 2Completed

Dasatinib as Therapy for Myeloproliferative Disorders (MPDs)

NCT03801434Phase 2Recruiting

Ruxolitinib in Treating Patients With Hypereosinophilic Syndrome or Primary Eosinophilic Disorders

NCT05334368Phase 3RecruitingPrimary

Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial

NCT00244686UnknownPrimary

This Record Contains Information About the Mepolizumab Compassionate Use (CU) Product Activities: 104317: CU and Long-Term Access Study of Mepolizumab in HES. 201956:A Long-term Access Programme for Subjects With Severe Asthma 112562: Expanded Access for Patients With Hypereosinophilic

NCT01524536Phase 4Completed

Steroid Treatment for Hypereosinophilic Syndrome

NCT00038675Not ApplicableCompleted

Therapy of HES, PV, Atypical Chronic Myelocytic Leukemia (CML) or Chronic Myelomonocytic Leukemia (CMML), and Mastocytosis With Imatinib Mesylate

NCT00109707Phase 1Completed

A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malignancies

NCT00230334Phase 2Terminated

Phase II Gleevec Idiopathic Hypereosinophilic Syndrome

NCT03306043Phase 3CompletedPrimary

A Multi-center, Open-label Extension, Safety Study of Mepolizumab in Subjects With Hypereosinophilic Syndrome (HES) From Study 200622

NCT00086658Phase 3Completed

Intravenous Mepolizumab In Subjects With Hypereosinophilic Syndromes (HES)

NCT02836496Phase 3CompletedPrimary

Efficacy and Safety Study of Mepolizumab in Subjects With Severe Hypereosinophilic Syndrome (HES)

NCT02581514Not ApplicableUnknownPrimary

Eosinophilia Diagnosis

NCT02101138Phase 2UnknownPrimary

Study to Evaluate Safety and Efficacy of Dexpramipexole (KNS-760704) in Subjects With Hypereosinophilic Syndrome

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