Key Insights

Highlights

Success Rate

65% trial completion

Published Results

15 trials with published results (15%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 59/100

Termination Rate

15.3%

15 terminated out of 98 trials

Success Rate

65.1%

-21.4% vs benchmark

Late-Stage Pipeline

1%

1 trials in Phase 3/4

Results Transparency

54%

15 of 28 completed with results

Key Signals

15 with results65% success15 terminated

Data Visualizations

Phase Distribution

84Total
Not Applicable (15)
Early P 1 (12)
P 1 (34)
P 2 (22)
P 4 (1)

Trial Status

Recruiting35
Completed28
Terminated15
Unknown6
Active Not Recruiting5
Not Yet Recruiting4

Trial Success Rate

65.1%

Benchmark: 86.5%

Based on 28 completed trials

Clinical Trials (98)

Showing 20 of 20 trials
NCT07206849Phase 2Not Yet Recruiting

Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)

NCT07416188Phase 1Recruiting

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

NCT05538130Phase 1Recruiting

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

NCT05023551Early Phase 1Active Not RecruitingPrimary

Study of DSP-0390 in Patients With Recurrent High-Grade Glioma

NCT05278208Phase 1RecruitingPrimary

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

NCT03952598Phase 2Suspended

Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy

NCT07710690Phase 1Recruiting

A Clinical Trial Evaluating the Tolerability, Safety, and Preliminary Efficacy of NRG-103 Injection in Patients With Recurrent or Progressive High-grade Glioma

NCT06712875Phase 1Recruiting

MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas

NCT03340506Phase 4Recruiting

Dabrafenib and/or Trametinib Rollover Study

NCT05835687Phase 1Active Not Recruiting

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

NCT07210632Early Phase 1Recruiting

Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)

NCT06333899Early Phase 1RecruitingPrimary

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

NCT06428045Phase 1RecruitingPrimary

STARLITE for Unresectable High-Grade Gliomas

NCT04573140Phase 1Recruiting

A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

NCT05565118Phase 1RecruitingPrimary

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

NCT05644080Not ApplicableCompletedPrimary

68Ga/177Lu-PSMA Theranostics in Recurrent Grade 3 and Grade 4 Glioma

NCT04485559Phase 1Recruiting

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

NCT06161974Phase 2RecruitingPrimary

Study of Olutasidenib and Temozolomide in HGG

NCT07644312Phase 2Not Yet RecruitingPrimary

Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG

NCT05839379RecruitingPrimary

Targeted Pediatric High-Grade Glioma Therapy

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