Key Insights

Highlights

Success Rate

72% trial completion

Published Results

57 trials with published results (28%)

Research Maturity

108 completed trials (52% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 64/100

Termination Rate

20.8%

43 terminated out of 207 trials

Success Rate

71.5%

-15.0% vs benchmark

Late-Stage Pipeline

12%

25 trials in Phase 3/4

Results Transparency

53%

57 of 108 completed with results

Key Signals

57 with results72% success43 terminated

Data Visualizations

Phase Distribution

186Total
Not Applicable (28)
Early P 1 (3)
P 1 (48)
P 2 (82)
P 3 (22)
P 4 (3)

Trial Status

Completed108
Terminated43
Unknown24
Recruiting13
Withdrawn10
Active Not Recruiting6

Trial Success Rate

71.5%

Benchmark: 86.5%

Based on 108 completed trials

Clinical Trials (207)

Showing 20 of 20 trials
NCT03602599CompletedPrimary

Chronic Graft-versus-Host Disease in the Oral Cavity of Patients Following Allogeneic Hematopoietic Stem Cell Transplant and Including Healthy Controls

NCT07235501RecruitingPrimary

Kinetic Analysis of Immune Cells in Blood and Chronic Graft-Versus-Host Disease-Affected Tissues After Allogeneic Hematopoietic Cell Transplantation

NCT07689630Phase 3RecruitingPrimary

Anti-CD25 Monoclonal Antibody for Prevention of Acute GVHD After Haploidentical HSCT

NCT02386800Phase 4Active Not Recruiting

CINC424A2X01B Rollover Protocol

NCT06996119Phase 1Recruiting

Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant

NCT07006506Phase 2RecruitingPrimary

A Study of Belumosudil in People at Risk of Developing Graft-Versus-Host Disease After a Stem Cell Transplant

NCT06815003Phase 2Recruiting

Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning

NCT00544115Phase 2Active Not Recruiting

Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders

NCT07611370Phase 1Not Yet RecruitingPrimary

Evaluating the Effects of Propionate and Butyrate Supplementation on the Intestinal Health of Healthy Volunteers

NCT06008808Phase 1Recruiting

Ruxolitinib With and Without CTLA-4 Ig Abatacept for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

NCT07356245Phase 2Recruiting

Ruxolitinib Maintenance Post-Hematopoietic Stem Cell Transplant T-Cell Lymphoma

NCT03192397Phase 1Active Not Recruiting

Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graft Versus Host Disease in Patients With Hematologic Malignancies Undergoing Donor Stem Cell Transplant

NCT01453140Phase 1TerminatedPrimary

In-vivo Regulatory T Cell Enhancement With Cyclophosphamide and Sirolimus

NCT06705062Phase 3Recruiting

Study Comparing Reduced Versus Standard Dose Post-transplantation Cyclophosphamide in Combination With Post-engraftment Anti-thymoglobin as Graft Versus Host Disease Prophylaxis in Alternative Donor Peripheral Stem Cell Transplantation

NCT03924401Phase 2Active Not RecruitingPrimary

Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant

NCT04886726Phase 1RecruitingPrimary

PTCY Plus uhCG/EGF for Graft Versus Host Disease Prophylaxis

NCT06252870Phase 2RecruitingPrimary

Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft Transplantation

NCT07319000Phase 2CompletedPrimary

Efficacy of Low-dose PT-Cy for Prevention of GVHD in Ambulatory Allogeneic HSCT

NCT04660487RecruitingPrimary

Relationship Between "FODMAPs" and "GVHD"

NCT03983850Phase 1Active Not RecruitingPrimary

Optimizing PTCy Dose and Timing

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Research Network

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