Key Insights

Highlights

Success Rate

56% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 60/100

Termination Rate

15.4%

4 terminated out of 26 trials

Success Rate

55.6%

-31.0% vs benchmark

Late-Stage Pipeline

8%

2 trials in Phase 3/4

Results Transparency

180%

9 of 5 completed with results

Key Signals

9 with results56% success

Data Visualizations

Phase Distribution

26Total
Not Applicable (2)
P 1 (11)
P 2 (11)
P 3 (2)

Trial Status

Recruiting9
Active Not Recruiting6
Completed5
Terminated4
Withdrawn1
Not Yet Recruiting1

Trial Success Rate

55.6%

Benchmark: 86.5%

Based on 5 completed trials

Clinical Trials (26)

Showing 20 of 20 trials
NCT04402788Phase 2RecruitingPrimary

Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

NCT04334941Phase 2Active Not RecruitingPrimary

Testing Maintenance Therapy for Small Cell Lung Cancer in Patients With SLFN11 Positive Biomarker

NCT06287775Phase 1RecruitingPrimary

Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

NCT05353439Phase 1Active Not RecruitingPrimary

Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung Cancer

NCT03896503Phase 2Active Not RecruitingPrimary

Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the Lungs

NCT04919382Phase 2RecruitingPrimary

Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer

NCT06769126Phase 2RecruitingPrimary

Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

NCT07423585Phase 2RecruitingPrimary

Tarlatamab for the Treatment of Extensive Stage Small-cell Lung Cancer

NCT03830918Phase 1Active Not Recruiting

Niraparib, Temozolomide and Atezolizumab in Treating Patients With Advanced Solid Tumors and Extensive-Stage Small Cell Lung Cancer With a Complete or Partial Response to Platinum-Based First-Line Chemotherapy

NCT04728230Phase 1Active Not RecruitingPrimary

Olaparib and Durvalumab With Carboplatin, Etoposide, and/or Radiation Therapy for the Treatment of Extensive-Stage Small Cell Lung Cancer, PRIO Trial

NCT04696575Phase 2RecruitingPrimary

Lamivudine in Combination With Chemoimmunotherapy for the Treatment of Extensive Stage Small Cell Lung Cancer

NCT05339022Not ApplicableCompleted

Supportive Care Intervention (ROAR-LCT) for Patients With Stage IIIA, IIIB, and IV Lung Cancer, ROAR-LCT Trial

NCT04560972Phase 1Active Not RecruitingPrimary

LB-100, Carboplatin, Etoposide, and Atezolizumab for the Treatment of Untreated Extensive-Stage Small Cell Lung Cancer

NCT05244239Phase 1RecruitingPrimary

Palliative Radiotherapy With Lurbinectedin in Patients With Extensive Stage Small Cell Lung Cancer

NCT04631029Phase 1CompletedPrimary

Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread

NCT03382561Phase 2CompletedPrimary

Cisplatin/Carboplatin and Etoposide With or Without Nivolumab in Treating Patients With Extensive Stage Small Cell Lung Cancer

NCT04155034Phase 3RecruitingPrimary

S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer

NCT01217411Phase 1Terminated

RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer

NCT06672133Phase 3Not Yet RecruitingPrimary

Adebrelimab Combined with Chemotherapy and Thoracic Radiotherapy for First-line Treatment of ES-SCLC

NCT05191797Phase 1TerminatedPrimary

Bomedemstat and Maintenance Immunotherapy for Treatment of Newly Diagnosed Extensive Stage Small Cell Lung Cancer

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