Key Insights

Highlights

Success Rate

71% trial completion

Published Results

15 trials with published results (21%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 59/100

Termination Rate

14.3%

10 terminated out of 70 trials

Success Rate

70.6%

-15.9% vs benchmark

Late-Stage Pipeline

1%

1 trials in Phase 3/4

Results Transparency

63%

15 of 24 completed with results

Key Signals

15 with results71% success

Data Visualizations

Phase Distribution

57Total
Not Applicable (4)
Early P 1 (2)
P 1 (31)
P 2 (19)
P 3 (1)

Trial Status

Completed24
Recruiting13
Active Not Recruiting11
Terminated10
Not Yet Recruiting8
Withdrawn4

Trial Success Rate

70.6%

Benchmark: 86.5%

Based on 24 completed trials

Clinical Trials (70)

Showing 20 of 20 trials
NCT04374305Phase 2Recruiting

Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)

NCT06804655Phase 2Not Yet Recruiting

Pharmacoscopy for Patients With Refractory Primary Brain Tumors

NCT05835687Phase 1Recruiting

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

NCT01096368Phase 3Completed

Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma

NCT00840047Phase 2Active Not Recruiting

Methionine PET/CT Studies In Patients With Cancer

NCT01445288Completed

Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

NCT05057702Not ApplicableRecruiting

Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma

NCT04185038Phase 1Recruiting

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

NCT03251989Completed

Rare CNS Tumors Outcomes &Risk

NCT06161519Phase 1Recruiting

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

NCT06639607Phase 1Not Yet Recruiting

PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma

NCT06193759Phase 1Recruiting

Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)

NCT03033992Not ApplicableActive Not Recruiting

Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG

NCT04978727Phase 1Active Not Recruiting

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

NCT04661384Phase 1Active Not RecruitingPrimary

Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

NCT04903080Phase 1Active Not RecruitingPrimary

HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma

NCT03152318Phase 1Active Not Recruiting

A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2

NCT02125786Phase 2Active Not RecruitingPrimary

A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma

NCT07424092Phase 2Not Yet Recruiting

Intratumoral DNX-2401 for High Grade Pediatric Brain Tumors

NCT07390539Phase 1Not Yet Recruiting

B7-H3.CD28Z.CART in CNS Neoplasms

Scroll to load more

Research Network

Activity Timeline