Key Insights

Highlights

Success Rate

68% trial completion

Published Results

17 trials with published results (23%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

14.7%

11 terminated out of 75 trials

Success Rate

67.6%

-18.9% vs benchmark

Late-Stage Pipeline

1%

1 trials in Phase 3/4

Results Transparency

74%

17 of 23 completed with results

Key Signals

17 with results68% success11 terminated

Data Visualizations

Phase Distribution

60Total
Not Applicable (4)
Early P 1 (2)
P 1 (32)
P 2 (21)
P 3 (1)

Trial Status

Completed23
Recruiting17
Active Not Recruiting12
Terminated11
Not Yet Recruiting7
Withdrawn4

Trial Success Rate

67.6%

Benchmark: 86.6%

Based on 23 completed trials

Clinical Trials (75)

Showing 20 of 20 trials
NCT01445288Completed

Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

NCT07031765Phase 1Active Not Recruiting

Peds CHAMP1ON - Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade for RecurreNt Pediatric High-Grade Glioma

NCT03251989Completed

Rare CNS Tumors Outcomes &Risk

NCT06804655Phase 2Recruiting

Pharmacoscopy for Patients With Refractory Primary Brain Tumors

NCT07061626Phase 1RecruitingPrimary

Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma

NCT06639607Phase 1Suspended

PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma

NCT07390539Phase 1Recruiting

B7-H3.CD28Z.CART in CNS Neoplasms

NCT04374305Phase 2Recruiting

Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)

NCT03173950Phase 2Terminated

Immune Checkpoint Inhibitor Nivolumab in People With Recurrent Select Rare CNS Cancers

NCT06161519Phase 1Recruiting

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

NCT05057702Not ApplicableRecruiting

Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma

NCT03900689Completed

Social Determinants of Health in Glioblastoma Population

NCT07703605Not Yet Recruiting

AI-Assisted MRI Molecular Subtyping in Pediatric Brain Tumors

NCT07713745Phase 2Not Yet Recruiting

Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2)

NCT07707947Phase 2Not Yet Recruiting

Selumetinib for NF2-Related Schwannomatosis

NCT05835687Phase 1Active Not Recruiting

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

NCT03194906Phase 2Completed

Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors

NCT06193759Phase 1Recruiting

Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)

NCT00840047Phase 2Active Not Recruiting

Methionine PET/CT Studies In Patients With Cancer

NCT06607692Phase 1Recruiting

Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).

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