Key Insights

Highlights

Success Rate

71% trial completion

Published Results

16 trials with published results (21%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 47/100

Termination Rate

13.3%

10 terminated out of 75 trials

Success Rate

70.6%

-16.0% vs benchmark

Late-Stage Pipeline

1%

1 trials in Phase 3/4

Results Transparency

67%

16 of 24 completed with results

Key Signals

16 with results71% success

Data Visualizations

Phase Distribution

60Total
Not Applicable (4)
Early P 1 (2)
P 1 (32)
P 2 (21)
P 3 (1)

Trial Status

Completed24
Recruiting14
Active Not Recruiting12
Not Yet Recruiting10
Terminated10
Withdrawn4

Trial Success Rate

70.6%

Benchmark: 86.5%

Based on 24 completed trials

Clinical Trials (75)

Showing 20 of 20 trials
NCT06161519Phase 1Recruiting

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

NCT03251989Completed

Rare CNS Tumors Outcomes &Risk

NCT07703605Not Yet Recruiting

AI-Assisted MRI Molecular Subtyping in Pediatric Brain Tumors

NCT07713745Phase 2Not Yet Recruiting

Platform Research for Innovative Medicines in NF2-SWN (PRIME-NF2)

NCT06639607Phase 1Suspended

PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma

NCT07707947Phase 2Not Yet Recruiting

Selumetinib for NF2-Related Schwannomatosis

NCT01445288Completed

Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

NCT05835687Phase 1Active Not Recruiting

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

NCT03900689Completed

Social Determinants of Health in Glioblastoma Population

NCT03194906Phase 2Completed

Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors

NCT06193759Phase 1Recruiting

Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT)

NCT00840047Phase 2Active Not Recruiting

Methionine PET/CT Studies In Patients With Cancer

NCT06607692Phase 1Recruiting

Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed).

NCT04903080Phase 1Active Not RecruitingPrimary

HER2-specific Chimeric Antigen Receptor (CAR) T Cells for Children With Ependymoma

NCT03033992Not ApplicableActive Not Recruiting

Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG

NCT04978727Phase 1Active Not Recruiting

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

NCT07424092Phase 2Recruiting

Intratumoral DNX-2401 for High Grade Pediatric Brain Tumors

NCT03750513Phase 1Recruiting

LET Optimized IMPT in Treating Pediatric Patients With Ependymoma

NCT07589361Not Yet Recruiting

Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation With Proton Therapy in Pediatric Tumors

NCT04374305Phase 2Recruiting

Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)

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