Key Insights

Highlights

Success Rate

40% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 60/100

Termination Rate

11.5%

3 terminated out of 26 trials

Success Rate

40.0%

-46.5% vs benchmark

Late-Stage Pipeline

4%

1 trials in Phase 3/4

Results Transparency

150%

3 of 2 completed with results

Key Signals

3 with results40% success

Data Visualizations

Phase Distribution

22Total
Not Applicable (1)
P 1 (16)
P 2 (4)
P 3 (1)

Trial Status

Recruiting15
Not Yet Recruiting3
Terminated3
Completed2
Active Not Recruiting1
Suspended1

Trial Success Rate

40.0%

Benchmark: 86.5%

Based on 2 completed trials

Clinical Trials (26)

Showing 20 of 20 trials
NCT05835687Phase 1Recruiting

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

NCT05843253Phase 2Recruiting

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

NCT05478837Phase 1Active Not RecruitingPrimary

Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma

NCT05839379Recruiting

Targeted Pediatric High-Grade Glioma Therapy

NCT04943848Phase 1Recruiting

rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

NCT05476939Phase 3Recruiting

Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0

NCT07389278Phase 1Not Yet Recruiting

Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)

NCT05762419Phase 1Recruiting

FUS Etoposide for DMG

NCT05077735Phase 2RecruitingPrimary

Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study

NCT06357377Phase 1Not Yet Recruiting

A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors

NCT04541082Phase 1Recruiting

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

NCT05259605Recruiting

Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification

NCT05009992Phase 2Recruiting

Combination Therapy for the Treatment of Diffuse Midline Gliomas

NCT06806228Phase 1Suspended

Phase I Pilot Study to Evaluate the Anti-glioblastoma Effect of S-Gboxin in Standard Treatment of Glioblastoma/Diffuse Midline Glioma and Response to Treatment (Regardless of Mutation Status)

NCT03101813Recruiting

International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository

NCT06624371Phase 1Recruiting

Atovaquone Combined With Radiation in Children With Malignant Brain Tumors

NCT04804709Phase 1Terminated

Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG)

NCT06161974Phase 2Recruiting

Study of Olutasidenib and Temozolomide in HGG

NCT02960230Phase 1Completed

H3.3K27M Peptide Vaccine With Nivolumab for Children With Newly Diagnosed DIPG and Other Gliomas

NCT05500508Phase 1Terminated

Oral AMXT 1501 Dicaprate in Combination With IV DFMO

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