Key Insights

Highlights

Success Rate

56% trial completion

Published Results

34 trials with published results (47%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 75/100

Termination Rate

20.5%

15 terminated out of 73 trials

Success Rate

55.9%

-30.7% vs benchmark

Late-Stage Pipeline

4%

3 trials in Phase 3/4

Results Transparency

179%

34 of 19 completed with results

Key Signals

34 with results56% success15 terminated

Data Visualizations

Phase Distribution

71Total
Not Applicable (2)
P 1 (28)
P 2 (38)
P 3 (3)

Trial Status

Active Not Recruiting21
Completed19
Terminated15
Recruiting14
Withdrawn3
Unknown1

Trial Success Rate

55.9%

Benchmark: 86.6%

Based on 19 completed trials

Clinical Trials (73)

Showing 20 of 20 trials
NCT06305598Phase 1Active Not RecruitingPrimary

Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer

NCT06145633Phase 2RecruitingPrimary

Vorinostat and 177Lu-PSMA-617 for the Treatment of PSMA-Low Metastatic Castration-Resistant Prostate Cancer

NCT03419234Phase 2Active Not Recruiting

Abiraterone Acetate and Antiandrogen Therapy With or Without Cabazitaxel and Prednisone in Treating Patients With Metastatic, Castration-Resistant Prostate Cancer Previously Treated With Docetaxel

NCT06632977Phase 2RecruitingPrimary

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

NCT02893917Phase 2Active Not Recruiting

Testing Two Oral Drugs Combination (Cediranib and Olaparib) Compared to a Single Drug (Olaparib) for Men With Advanced Prostate Cancer

NCT05828082Phase 2Active Not RecruitingPrimary

Testing the Effect of M1774 on Hard-to-Treat Refractory SPOP-mutant Prostate Cancer

NCT03517969Phase 2Active Not RecruitingPrimary

M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

NCT03317392Phase 1Active Not RecruitingPrimary

Testing the Safety of Different Doses of Olaparib Given Radium-223 for Men With Advanced Prostate Cancer With Bone Metastasis

NCT05113537Phase 1RecruitingPrimary

Abemaciclib Before 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer

NCT06942104Phase 1Recruiting

Imaging of Solid Tumors Using 18F-TRX

NCT04471974Phase 2Active Not RecruitingPrimary

ZEN-3694, Enzalutamide, and Pembrolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer

NCT05689021Phase 2TerminatedPrimary

CJNJ-67652000 and Prednisone for Treatment of Metastatic Castration-Resistant Prostate Cancer and SPOP Gene Mutations

NCT06039371Phase 2RecruitingPrimary

Supraphysiological Androgen to Enhance Treatment Activity in Metastatic Castration-Resistant Prostate Cancer, SPECTRA Study

NCT04550494Phase 2Active Not Recruiting

Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

NCT05398302Phase 1RecruitingPrimary

Image-Guided Biopsies to Identify Mechanisms of Resistance in Patients With Metastatic Castration Resistant Prostate Cancer Treated With 177Lu-PSMA Radioligand Therapy

NCT04592237Phase 2Active Not Recruiting

Cabazitaxel, Carboplatin, and Cetrelimab Followed by Niraparib With or Without Cetrelimab for the Treatment of Aggressive Variant Metastatic Prostate Cancer

NCT05730712Phase 2CompletedPrimary

Pertuzumab, Trastuzumab, Hyaluronidase-zzxf and Enzalutamide for Treatment of Metastatic Castration-Resistant Prostate Cancer

NCT05168618Phase 2RecruitingPrimary

Cabozantinib and Atezolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer

NCT03344211Phase 2Active Not RecruitingPrimary

Enzalutamide With or Without Radium Ra 223 Dichloride in Patients With Metastatic, Castration-Resistant Prostate Cancer

NCT03873805Phase 1Active Not RecruitingPrimary

PSCA-CAR T Cells in Treating Patients With PSCA+ Metastatic Castration Resistant Prostate Cancer

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Research Network

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