Key Insights

Highlights

Success Rate

67% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 72/100

Termination Rate

14.3%

3 terminated out of 21 trials

Success Rate

66.7%

-19.8% vs benchmark

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

17%

1 of 6 completed with results

Key Signals

1 with results67% success

Data Visualizations

Phase Distribution

15Total
Early P 1 (1)
P 1 (7)
P 2 (7)

Trial Status

Completed6
Recruiting5
Terminated3
Not Yet Recruiting2
Unknown2
Withdrawn1

Trial Success Rate

66.7%

Benchmark: 86.5%

Based on 6 completed trials

Clinical Trials (21)

Showing 20 of 20 trials
NCT04074096Phase 2Active Not Recruiting

Binimetinib Encorafenib Pembrolizumab +/- Stereotactic Radiosurgery in BRAFV600 Melanoma With Brain Metastasis

NCT07110246Phase 2RecruitingPrimary

Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas

NCT05786924Phase 1Recruiting

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

NCT07122882Enrolling By Invitation

Integrated Genomics in Oncogene-driven NSCLC With Acquired Resistance

NCT04741997Early Phase 1Recruiting

Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanoma

NCT04911998Completed

A Prospective Observational Study on Targeted Therapy for Unresectable or Metastatic BRAFV600E Mutant Melanoma Patients

NCT05510895Phase 2Completed

Neoadjuvant Encorafenib, Binimetinib and Cetuximab for Patients With BRAF V600E Mutated/pMMR Localized Colorectal Cancer

NCT05546905Completed

A Study in Patients With BRAF V600E-mutant Metastatic Non-small Cell Lung Cancer (OCTOPUS)

NCT05275374Phase 1Not Yet Recruiting

XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation

NCT06749015Recruiting

A Study on Treatment for Patients With BRAFV600E Mutant Metastatic Colorectal Cancer (mCRC)

NCT05501912Phase 1Terminated

A Study of ABM-1310 in Patients With BRAF V600-Mutant Advanced Solid Tumors

NCT05810740Phase 1Completed

Bioequivalence Binimetinib 3 x 15 mg and 45 mg Formulations

NCT04190628Phase 1Terminated

Safety and Tolerability of ABM-1310 in Patients With Advanced Solid Tumors

NCT06054191Phase 2Not Yet Recruiting

Neoadjuvant and Adjuvant Targeted Treatment in NSCLC With BRAF V600 or MET Exon 14 Mutations

NCT03430947Phase 2Terminated

Vemurafenib Plus Cobimetinib After Radiosurgery in Patients With BRAF-mutant Melanoma Brain Metastases

NCT05800340Phase 2Recruiting

Neoadjuvant Immunotherapy in Rare Mutations Localized NSCLC

NCT04759846Phase 1WithdrawnPrimary

Hepatic Impairment Study of Encorafenib in Combination With Binimetinib in BRAF Melanoma

NCT04775095Completed

BRAF V600-mutated Lung Carcinoma Treated With the Combination of Dabrafenib-trametinib: a Retrospective Evaluation

NCT03514901Phase 2Unknown

To Evaluate the Efficacy Beyond Progression of Vemurafenib+Cobimetinib Associated With Local Treatment Compared to Second-line Treatment in Patients With BRAFV600+ Metastatic Melanoma in Focal Progression With First-line+Vemurafenib+Cobimetinib.

NCT05103891Phase 1Unknown

Relative Bioavailability of Binimetinib 3 x 15 mg and 45 mg Formulations

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