Key Insights

Highlights

Success Rate

67% trial completion

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 72/100

Termination Rate

13.3%

2 terminated out of 15 trials

Success Rate

66.7%

-19.8% vs benchmark

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

0%

0 of 4 completed with results

Key Signals

67% success

Data Visualizations

Phase Distribution

14Total
P 1 (12)
P 2 (2)

Trial Status

Completed4
Recruiting3
Active Not Recruiting3
Terminated2
Withdrawn2
Not Yet Recruiting1

Trial Success Rate

66.7%

Benchmark: 86.5%

Based on 4 completed trials

Clinical Trials (15)

Showing 15 of 15 trials
NCT05835687Phase 1Recruiting

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

NCT05934630Terminated

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

NCT05286801Phase 1Active Not RecruitingPrimary

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

NCT06465199Phase 1RecruitingPrimary

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

NCT04185038Phase 1Recruiting

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

NCT07390539Phase 1Not Yet Recruiting

B7-H3.CD28Z.CART in CNS Neoplasms

NCT03500991Phase 1Active Not Recruiting

HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

NCT03638167Phase 1Completed

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

NCT04416568Phase 2Active Not Recruiting

Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

NCT04897880Phase 2Terminated

A Study of Panobinostat in Pediatric Patients With Solid Tumors Including MRT/ATRT

NCT04521946Phase 1Withdrawn

Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer

NCT03434262Phase 1Completed

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors

NCT05952687Phase 1Withdrawn

Trial of Idasanutlin and Selinexor Therapy for Children With Progressive/Relapsed AT/RT or Extra-CNS Malignant Rhabdoid Tumors

NCT02962167Phase 1Completed

Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT

NCT01331135Phase 1Completed

Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors

Showing all 15 trials

Research Network

Activity Timeline