Key Insights

Highlights

Success Rate

74% trial completion

Published Results

16 trials with published results (19%)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 59/100

Termination Rate

15.1%

13 terminated out of 86 trials

Success Rate

74.0%

-12.5% vs benchmark

Late-Stage Pipeline

6%

5 trials in Phase 3/4

Results Transparency

43%

16 of 37 completed with results

Key Signals

16 with results74% success13 terminated

Data Visualizations

Phase Distribution

67Total
Not Applicable (9)
Early P 1 (5)
P 1 (27)
P 2 (21)
P 3 (4)
P 4 (1)

Trial Status

Completed37
Recruiting14
Terminated13
Unknown8
Active Not Recruiting7
Withdrawn3

Trial Success Rate

74.0%

Benchmark: 86.5%

Based on 37 completed trials

Clinical Trials (86)

Showing 20 of 20 trials
NCT03911388Phase 1Recruiting

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

NCT06344130Phase 1RecruitingPrimary

Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma

NCT07417761Phase 2RecruitingPrimary

Tuvusertib in Astrocytoma With ATRX Mutation

NCT03975829Phase 4Active Not Recruiting

Pediatric Long-Term Follow-up and Rollover Study

NCT03796273Early Phase 1Terminated

Ketoconazole Before Surgery in Treating Patients With Recurrent Glioma or Breast Cancer Brain Metastases

NCT05393258Not ApplicableCompletedPrimary

Temporally-modulated Pulsed Radiation Therapy (TMPRT) After Prior EBRT for Recurrent IDH-mutant Gliomas

NCT05484622Phase 1Active Not RecruitingPrimary

Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive IDH-1 Mutant Glioma

NCT03152318Phase 1Active Not Recruiting

A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2

NCT07439172Phase 2Not Yet Recruiting

Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.

NCT02942264Phase 1Terminated

Zotiraciclib (TG02) Plus Dose-Dense or Metronomic Temozolomide Followed by Randomized Phase II Trial of Zotiraciclib (TG02) Plus Temozolomide Versus Temozolomide Alone in Adults With Recurrent Anaplastic Astrocytoma and Glioblastoma

NCT05345002Phase 2Recruiting

All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

NCT05683808Phase 2Recruiting

Venous Thromboembolism Prevention in Outpatients With Glioma

NCT05236036Phase 1Active Not RecruitingPrimary

Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma

NCT05686798Phase 1Recruiting

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

NCT06439420Phase 2Completed

CBT-I in Primary Brain Tumor Patients: Phase IIc Randomized Feasibility Pilot Trial

NCT01849952TerminatedPrimary

Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas

NCT06989086Not ApplicableRecruiting

FearLess in NeuroOncology

NCT06614855Phase 1Active Not Recruiting

A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma

NCT04135807Early Phase 1Recruiting

Implantable Microdevice In Primary Brain Tumors

NCT03739372Not ApplicableActive Not Recruiting

Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma

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