Key Insights

Highlights

Success Rate

74% trial completion

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 49/100

Termination Rate

13.5%

5 terminated out of 37 trials

Success Rate

73.7%

-12.8% vs benchmark

Late-Stage Pipeline

19%

7 trials in Phase 3/4

Results Transparency

43%

6 of 14 completed with results

Key Signals

6 with results74% success

Data Visualizations

Phase Distribution

26Total
Not Applicable (7)
Early P 1 (1)
P 1 (3)
P 2 (8)
P 3 (7)

Trial Status

Completed14
Recruiting7
Terminated5
Active Not Recruiting4
Unknown4
Withdrawn2

Trial Success Rate

73.7%

Benchmark: 86.5%

Based on 14 completed trials

Clinical Trials (37)

Showing 20 of 20 trials
NCT07444489Phase 3Enrolling By InvitationPrimary

A Study to Learn More About the Long-Term Safety and Effects of Felzartamab Infusions in Adults With Kidney Transplants Who Have Antibody-Mediated Rejection (AMR)

NCT06744647Phase 2RecruitingPrimary

Phase 2 Study of ALXN2030 in Patients With Antibody-Mediated Rejection After Kidney Transplantation

NCT06503731Phase 2RecruitingPrimary

A Study to Evaluate the Safety and Tolerability of Efgartigimod PH20 SC Given by Prefilled Syringe in Kidney Transplant Recipients With Antibody-Mediated Rejection (AMR)

NCT06685757Phase 3RecruitingPrimary

A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Kidney Transplants Who Have Antibody-Mediated Rejection (AMR)

NCT07316829Active Not Recruiting

TRAnscriptional Profile of Peripheral Blood Cells in Patient With Chronic Kidney and Lung Rejection: Correlation With Response to Extracorporeal Photo-aphereSiS

NCT03719339Active Not Recruiting

VIRTUUS Children's Study

NCT03737136Not ApplicableCompletedPrimary

Comparison Between Bortezomib and Rituximab Plus Plasmapheresis in AMR

NCT03744910Phase 3TerminatedPrimary

Clazakizumab for the Treatment of Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients

NCT05004493RecruitingPrimary

Biorepository and Registry for Plasma Exchange Patients

NCT04541914Not ApplicableCompleted

Diagnostic Efficacy of Molecular Diagnostic Method for AMR in ABOiKT

NCT03380377Phase 1CompletedPrimary

Clazakizumab for Chronic and Active Antibody Mediated Rejection Post-Kidney Transplant

NCT03994783Phase 3Terminated

Transplant Antibody-Mediated Rejection: Guiding Effective Treatments

NCT05862766Early Phase 1WithdrawnPrimary

Isatuximab in Lung Transplant Recipients

NCT04561986Phase 3RecruitingPrimary

TocIlizumab in Late/Chronic Active Antibody-mediated Rejection in Kidney Transplant Recipients

NCT03380962Phase 1Active Not Recruiting

Clazakizumab in Highly-HLA Sensitized Patients Awaiting Renal Transplant

NCT04897438Not ApplicableCompleted

Donor-derived Cell-free DNA for Early Diagnosis of Antibody-mediated Rejection

NCT06112951Not ApplicableRecruitingPrimary

A Prospective Randomized Trial of ECP in Subclinical AMR

NCT05021484Phase 2CompletedPrimary

Felzartamab in Late Antibody-Mediated Rejection

NCT04204980Phase 1Completed

Desensitization in Kidney Allograft Using Daratumumab

NCT05913596Not ApplicableUnknownPrimary

The Safety and Efficacy of CD38 Monoclonal Antibody Monotherapy for CaAMR in Renal Transplantation

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