SYFd679acc07b0b4d5990103224ed764f76Registry ID: 2024-516025-30-00|RecruitingPhase 2
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interventional
N/A
1 country
2
a) To determine the optimal time point acquisition of [18F]TFB PET/CT, b) to determine the value of [18F]TFB PET/CT for detection of (pre-operative) metastatic lymph node(s) in patients with differentiated thyroid cancer and c) to determine the value of [18F]TFB PET/CT for the estimation of radioiodine therapy response in patients with persistent and recurrent differentiated thyroid cancer.
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December 3, 2024
Actual (reported)Optimal time kinetic point and number and localization of lymph node metastases + predictive 131I therapy response
Analysis of reference standards: ultrasonography, pathology and post-therapy 131I scan (these tests are performed under regular clinical care)
To study [18F]TFB kinetics in normal thyroid tissue, in primary thyroid tumor tissue, in lymph node metastases and in distant metastases (SUVmax, tumorto-background ratio). - To analyse the possible correlation between [18F]TFB uptake and NISmembrane expression levels, as determined by immunohistochemistry. - To assess whether [18F]TFB PET/CT might be advisable especially for patients with minimally elevated tumor marker levels.
Universitair Medisch Centrum Utrecht
Utrecht, 3584 CG, Netherlands
Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Rotterdam, 3015 GJ, Netherlands
Prof. dr. Frederik Verburg
First Submitted
December 3, 2024
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