NCT07896395|Completed
20-20-20 Rule Plus Artificial Tears for Dry Eye
Artificial Tears Alone Versus Combined Artificial Tears and the 20-20-20 Rule in the Management of Dry Eye in Digital Device Users
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Artificial Tears Alone Versus Combined Artificial Tears and the 20-20-20 Rule in the Management of Dry Eye in Digital Device Users
Sponsor study identifier
interventional
48
1 country
1
Study Start
September 10, 2025
Actual (reported)Primary Completion
March 31, 2026
Actual (reported)Study Completion
March 31, 2026
Actual (reported)This study is for anyone struggling with dry, tired, or uncomfortable eyes, especially from long hours on screens. We all know that feeling after staring at a laptop or phone too long. This study from Zagazig University looks at a simple habit called the 20-20-20 rule: every 20 minutes, take a 20-second break to look at something about 20 feet away. We want to see if doing this every day, along with your regular artificial tears, helps your eyes feel better than tears alone. If you join, you will use artificial tears as usual. Some participants will also be asked to practice the 20-20-20 rule throughout the day. We will follow you for about 8 weeks and check your symptoms, tear film, and overall eye comfort with simple eye exams and questionnaires. There is no experimental drug involved, just a daily habit we hope will make standard treatment work better. The study was approved by the Institutional Review Board, Faculty of Medicine, Zagazig University on 07-September-2024.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 31, 2026
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 10, 2025
Actual (reported)March 31, 2026
Actual (reported)March 31, 2026
Actual (reported)October 20, 2026
Actual (reported)October 27, 2026
Actual (reported)Change in Ocular Surface Disease Index (OSDI) score from baseline to 3 months.
OSDI is a 12-item validated questionnaire scored 0-100, with higher scores indicating more severe symptoms.
Assessed at baseline, 6 weeks, and 3 months
Change in Non-Invasive Keratograph Break-Up Time (NIKBUT)
Assessed at baseline, 6 weeks, and 3 months.
Change in Central Lower Tear Meniscus Height (TMH)
Assessed at baseline, 6 weeks, and 3 months.
Change in Bulbar Conjunctival Redness Score
Assessed at baseline, 6 weeks, and 3 months.
Change in Meibomian Gland Loss
Assessed at baseline, 6 weeks and 3 months
\*Arm 1 Description:\* Preservative-free artificial tears (sodium hyaluronate), 1 drop in each affected eye 4 times daily for 3 months. No 20-20-20 rule intervention.
\*Arm 2 Description:\* Same artificial tears regimen as Arm 1 (1 drop in each affected eye 4 times daily for 3 months) PLUS the 20-20-20 rule (every 20 minutes, look at something 20 feet away for 20 seconds), reinforced by an eye-blink reminder application during work hours for 3 months.
1\. Artificial Tears (Drug): for arm 1 Preservative-free sodium hyaluronate ophthalmic solution, 1 drop in each eye 4 times daily for 3 months. Standard lubricating therapy for video display terminal-associated dry eye, given to both arms as background treatment.
Participants are instructed to follow the 20-20-20 rule during all video display terminal use: every 20 minutes of continuous screen work, look at an object at least 20 feet (6 meters) away for at least 20 seconds, accompanied by 5 conscious, complete blinks. To reinforce adherence, participants install an eye-blink reminder application on their phone/work computer that prompts every 20 minutes during work hours. Training on the rule is provided at baseline with a written leaflet. Duration: throughout the 3-month study period, during work hours (approx. 8 hours/day).
Ophthalmology Department, Zagazig University Hospital
Zagazig, Sharkeya, 445511, Egypt
El-Mashed GY, Salama MAA, Srour LSS, Saleh AMA; Artificial Tears Alone versus Combined Artificial Tears and the 20-20-20 Rule in the Management of Dry Eye in Digital Device Users; Unpublished manuscript, Ophthalmology Department, Faculty of Medicine, Zagazig University; 2025; -;
Alaa M Saleh, MD
Zagazig University
48 participants (actual enrollment reported by the registry).
First Submitted
October 20, 2026
First Posted
October 27, 2026
Effects of 3% Diquafosol on Tear Film and Vision-related Quality of Life in Orthokeratology Lens Related Dry Eye
Contact the study team to confirm eligibility.
Study Start
September 10, 2025
Actual (reported)Primary Completion
March 31, 2026
Actual (reported)Study Completion
March 31, 2026
Actual (reported)Last Updated
October 27, 2026
Record last verified: 2026-10
De-identified Individual Participant Data (IPD) for all 48 participants will be shared, including:Demographics: Age, Sex, Occupation (IT employee)Treatment Assignment: Group A (Preservative-free artificial tears 4x daily) vs Group B (Same artificial tears + 20-20-20 rule with reminder app)Visit Data at Baseline, First Follow-up (1 month), and Second Follow-up (3 months):Ocular Surface Disease Index (OSDI) scoreNon-invasive tear break-up time (NIBUT) (seconds)Tear Meniscus Height (TMH) (mm)Lipid layer assessmentBulbar redness scanMeibomian gland opening (Normal/Mild/Moderate)Meibomian gland dysfunction (MGD) score (0/1/2)Data will be provided as a de-identified participant-level dataset with a data dictionary, along with the Study Protocol and Statistical Analysis Plan.
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