NCT07894783|Not Yet RecruitingDMC
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Sponsor study identifier
interventional
60
0 countries
N/A
Study Start
January 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
January 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This study aims to estimate the 90% effective dose (ED₉₀) of norepinephrine and phenylephrine infusions for the prevention of maternal hypotension in patients of advanced maternal age undergoing cesarean section, using the sequential allocation method.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 19, 2026
Actual (reported)October 26, 2026
Actual (reported)January 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
January 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
January 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
ED90
The ED90 of norepinephrine and phenylephrine infusion for prevention of maternal hypotension under spinal anesthesia
1-15 minutes after spinal anesthesia
The incidence of post-spinal anesthesia hypotension
1-15 minutes after spinal anesthesia.
The incidence of severe post-spinal anesthesia hypotension.
1-15 minutes after spinal anesthesia.
pH
Immediately after delivery
APGAR score
1 minute after delivery
APGAR score
5 minute after delivery
The maternal systolic blood pressure was consistently maintained above 80% of the preoperative baseline value from the initiation of spinal anesthesia until fetal delivery.
The maternal systolic blood pressure was consistently maintained above 80% of the preoperative baseline value from the initiation of spinal anesthesia until fetal delivery.
An initial infusion dose of prophylactic norepinephrine (0.05 ug/kg/min) simultaneous with spinal anesthesia. The dose administered to subsequent patients varied by increments or decrements of 0.01 ug/kg/min of prophylactic norepinephrine according to the responses of previous patients according to the up down sequential allocation.
An initial infusion dose of prophylactic norepinephrine (0.5 ug/kg/min) simultaneous with spinal anesthesia. The dose administered to subsequent patients varied by increments or decrements of 0.1 ug/kg/min of prophylactic norepinephrine according to the responses of previous patients according to the up down sequential allocation.
Yi Chen
General Hospital of Ningxia Medical University
First Submitted
October 19, 2026
First Posted
October 26, 2026
Study Start
January 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
January 31, 2027
Norepinephrine and Phenylephrine for Spinal Anesthesia-induced Hypotension.
Contact the study team to confirm eligibility.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
January 31, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 26, 2026
Record last verified: 2026-10
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