Stress Hyperglycemia Ratio and Glucose Variability in Critically Ill Patients

NCT07892222 | Not Yet Recruiting

• 1 other identifier: SHR-GV-ICU-Assiut-2026
• Study Type: observational
• Target: 75
• Locations: 0 countries
• Sites: N/A

Brief Summary

This prospective cohort study aims to evaluate the stress hyperglycemia ratio and glucose variability among critically ill patients admitted to the intensive care unit.

Conditions

Critical Illness; Hyperglycemia

Keywords

Critically ill; Stress hyperglycemia ratio; Glucose variability; ICU mortality; Assiut

Outcome Measures

Primary Outcomes (1)

• Number of deaths

  Number of patients who die from any cause within 28 days from intensive care unit admission.

  At 28 days

Secondary Outcomes (4)

• Stress hyperglycemia ratio

  Baseline

• Glucose coefficient of variation

  At 24 hours

• ICU length of stay

  At 28 days

• Number of patients requiring mechanical ventilation

  At 28 days

Study Arms (1)

Critically Ill Patients

Adult patients admitted to the intensive care unit who will undergo calculation of stress hyperglycemia ratio and glucose variability indices.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients aged 18 years or older admitted to the intensive care unit at Assiut University Hospital with an expected stay of at least 24 hours.

You may qualify if:

• Adult patients aged 18 years or older
• Admitted to the ICU with expected stay of at least 24 hours
• HbA1c and admission blood glucose obtainable within the first 24 hours
• Written informed consent from the patient or legal guardian

You may not qualify if:

• \- Age less than 18 years
• Death or ICU discharge within 24 hours of admission
• Pregnancy
• Diabetic ketoacidosis or hyperosmolar hyperglycemic state at presentation
• Conditions that falsely alter HbA1c
• Fewer than 3 glucose measurements in the first 24 hours
• Terminal illness with palliative or do-not-resuscitate decision
• Refusal of consent

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Critical Illness; Hyperglycemia

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Ahmed M Obaidullah, prof

  Internal Medicine Department, Assiut University Hospitals

  STUDY CHAIR

Central Study Contacts

Andraws H Abdo, Resident

CONTACT

01554575509; andraws.18313318@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident Physician, Department of Internal Medicine

Study Record Dates

• First Submitted: October 17, 2026
• First Posted: October 23, 2026
• Study Start: October 20, 2026
• Primary Completion (Estimated): October 20, 2027
• Study Completion (Estimated): March 10, 2028
• Last Updated: October 23, 2026

Record last verified: 2026-10

Data Sharing

• IPD Sharing: Will not share