Customized CBCT-Based Assessment of Transverse Discrepancies

NCT07887308 | Active Not Recruiting

• 1 other identifier: ORTH 1.2.1
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective cross-sectional observational study aims to develop a customized, patient-specific CBCT-based method for assessing skeletal transverse discrepancies independent of dental compensation. A total of 120 previously acquired CBCT scans of patients aged 15-30 years will be evaluated and equally divided into skeletal Class I, Class II, and Class III groups (40 scans per group). The study will assess transverse skeletal and dental relationships using standardized CBCT measurements and will evaluate the intra- and inter-examiner reproducibility of the proposed methodology. The distribution and pattern of transverse discrepancies among the three skeletal classes will also be assessed.

Conditions

Transverse Skeletal Discrepancy

Keywords

Cone-Beam Computed Tomography (CBCT) Transverse Discrepancy Dental Compensation Skeletal Malocclusion Molar Inclination; Cone-Beam Computed Tomography (CBCT); Transverse Discrepancy; Dental Compensation; Skeletal Malocclusion; Molar Inclination; Maxillomandibular Transverse Relationship

Outcome Measures

Primary Outcomes (1)

• Customized Patient-Specific CBCT-Based Assessment of Skeletal Transverse Discrepancy

  Measurement of skeletal transverse discrepancy using a customized, patient-specific CBCT-based approach, independent of dental compensation.

  Baseline (at the time of CBCT acquisition)

Secondary Outcomes (1)

• Intra- and Inter-Examiner Reproducibility of the Customized CBCT Methodology

  2 weeks

Study Arms (3)

Skeletal Class I

CBCT scans of 40 patients with a skeletal Class I sagittal relationship.

Skeletal Class II

CBCT scans of 40 patients with a skeletal Class II sagittal relationship.

Skeletal Class III

BCT scans of 40 patients with a skeletal Class III sagittal relationship.

Eligibility Criteria

• Age: 15 Years - 30 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 15-30 years with skeletal Class I, Class II, or Class III patterns. A total of 120 previously acquired CBCT scans meeting the eligibility criteria will be retrospectively selected and equally divided into three groups: 40 Class I, 40 Class II, and 40 Class III.

You may qualify if:

• Patients aged 15-30 years.
• Skeletal Class I, II, or III malocclusion.
• High-quality CBCT scans showing both the maxilla and mandible.
• Both male and female patients.

You may not qualify if:

• History of previous orthodontic or orthopedic treatment.
• Craniofacial anomalies or syndromes.
• Systemic conditions affecting craniofacial growth.
• Severe maxillofacial pathology affecting skeletal structures.
• Poor-quality or incomplete CBCT scans.

Sponsors & Collaborators

• October University for Modern Sciences and Arts: lead

Study Sites (1)

Faculty of Dentistry, MSA University

Giza, Giza Governorate, Egypt

Location

Related Publications (3)

• Diez-Rodrigalvarez D, Bonilla-Morente E, Lopez-Jimenez AJ. A Novel Method for the Diagnosis of Transverse Maxillary Deficiencies Based on CBCT. Diagnostics (Basel). 2026 Mar 30;16(7):1034. doi: 10.3390/diagnostics16071034.

  PMID: 41975748 BACKGROUND

• Miner RM, Al Qabandi S, Rigali PH, Will LA. Cone-beam computed tomography transverse analyses. Part 2: Measures of performance. Am J Orthod Dentofacial Orthop. 2015 Aug;148(2):253-63. doi: 10.1016/j.ajodo.2015.03.027.

  PMID: 26232834 BACKGROUND

• Miner RM, Al Qabandi S, Rigali PH, Will LA. Cone-beam computed tomography transverse analysis. Part I: Normative data. Am J Orthod Dentofacial Orthop. 2012 Sep;142(3):300-7. doi: 10.1016/j.ajodo.2012.04.014.

  PMID: 22920695 BACKGROUND

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 7, 2026
• First Posted: October 21, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): August 1, 2027
• Last Updated: October 21, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)