NCT07885189

Brief Summary

TuCAN-Media is a longitudinal study investigating cognitive recovery after stroke in severely affected patients (modified Rankin Scale \[mRS\] score ≥ 3) with large vessel occlusion of the arteria cerebri media/middle cerebral artery (MCA). Cognitive functioning and recovery will be assessed in a comprehensive multi-domain digital-based cognitive testing using the TuCAN-App to facilitate a standardized and rapid testing during the acute phase of a stroke (V2), as well as at 3month(V3)- and 6-month (V4) follow-ups.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for all trials

Timeline
3mo left

Started Jul 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress82%
Jul 2025Feb 2027

Study Start

First participant enrolled

July 1, 2025

Completed
29 days until next milestone

First Submitted

Initial submission to the registry

July 30, 2025

Completed
1.2 years until next milestone

First Posted

Study publicly available on registry

October 21, 2026

Completed
11 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2026

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2027

Last Updated

October 21, 2026

Status Verified

October 1, 2026

Enrollment Period

1.3 years

First QC Date

July 30, 2025

Last Update Submit

October 15, 2026

Conditions

Cognitive Recovery After StrokeCognitive Outcome After Stroke

Keywords

cognitive outcome after strokecognitive recovery after strokecognitive assessment in stroke patientsdigital-based cognitive assessment

Outcome Measures

Primary Outcomes (1)

  • Group comparision (Rec+ vs. Rec-) of cognitive function between acute stroke and at 3 month follow-up

    Group comparison of cognitive function between visit 2 (V2) and visit 3 (V3) in patients with and without successful recanalization as assessed by the St. Louis University Mental Status (SLUMS) examination total score

    3 months

Secondary Outcomes (1)

  • Group comparision (Rec+ vs. Rec-) of cognitive function between 3 months and 6 months follow-up

    6 months

Study Arms (2)

Rec+

after successfull recanalization (thrombectomy)

Rec-

after unsucessfull recanalization (thrombectomy)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

primary care clinic

You may qualify if:

  • ≥ 18 years of age
  • Right- or left-hemispheric MCA occlusion (MCA segments M1-M3 or corresponding perfusion deficit)
  • modified Rankin Scale (mRS) score ≥ 3 at the time of the index event
  • Informed consent from the patient or their legal representative

You may not qualify if:

  • ≤ 18 years of age
  • Pregnancy
  • Pre-existing severe dementia

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Neurology; University Hospital

Tübingen, Germany

RECRUITING

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 30, 2025

First Posted

October 21, 2026

Study Start

July 1, 2025

Primary Completion (Estimated)

November 1, 2026

Study Completion (Estimated)

February 1, 2027

Last Updated

October 21, 2026

Record last verified: 2026-10

Data Sharing

IPD Sharing
Will not share

Locations

DE(1)