NCT07885007

Brief Summary

To examined the opportunity for Artificial Intelligence (AI) agents to evaluate transplant candidacy objectively at LT-SC, with a large language models (LLM) representing the expertise of each individual specialist (hepatologist, surgeon, anesthesiologist, psychiatrist and social worker) and coming up with a group consensus decision upon inter-agent communication using prompts GPT-4 in OpenAI (private version).

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,000

participants targeted

Target at P75+ for all trials

Timeline
14mo left

Started Apr 2026

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress32%
Apr 2026Dec 2027

Study Start

First participant enrolled

April 1, 2026

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

October 13, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

October 21, 2026

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2026

Expected
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2027

Last Updated

October 21, 2026

Status Verified

May 1, 2026

Enrollment Period

9 months

First QC Date

October 13, 2026

Last Update Submit

October 13, 2026

Conditions

Liver Cirrhosis

Keywords

AI-SC Agent Multicenter

Outcome Measures

Primary Outcomes (2)

  • Concordance of AI-SC vs LT-SC review

    · Our primary outcome will be any substantial change in the content, method, or result of the patient assessment between the AI-SC and conventional reports. We will calculate the percentage of concordance between the two, and the similarity of report generated by the human and the AI-SC will be evaluated using ROUGE score (Recall-Oriented Understudy for Gisting Evaluation), a quantitative metric that assesses textual similarity3.

    3 months

  • Concordance between AI-SC vs LT-SC

    Our primary outcome will be any substantial change in the content, method, or result of the patient assessment between the AI-SC and conventional reports. We will calculate the percentage of concordance between the two, and the similarity of report generated by the human and the AI-SC will be evaluated using ROUGE score (Recall-Oriented Understudy for Gisting Evaluation), a quantitative metric that assesses textual similarity3

    3 months

Secondary Outcomes (1)

  • Time of adjudication

    3 months

Study Arms (2)

AI-SC

AI - Selection Committee

Other: evaluate the alignment between AI-SC recommendations and LT-SC decisionsOther: Multi AI-SC model

Human Liver transplant (LT)-SC

Human Liver Transplant Selection Committee

Interventions

Multi AI-SC modelOTHER

To evaluate the feasibility and acceptability of integrating such multi AI-SC(Selection Committee) agents into LT candidate assessments.

AI-SC
evaluate the alignment between AI-SC recommendations and LT-SC decisionsOTHER

To validate the developed model, we invited other collaborating centers, including Vancouver Coastal Health (Canada), Mayo Clinic (US), John Hopkins Hospital (US), Royal Prince Alfred Hospital (AU), National University of Singapore (Singapore), UCSF Health (US), Vanderbilt University Medical Center (US), John Hopkins Hospital (US), MeDanTa (India), and Ministry of National Guard Health Affairs (Saudi Arabia) to perform a validation as an extension of data governance phase.

AI-SC

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

patient with liver cirrhosis on evaluation for liver transplant

You may qualify if:

  • patient more or equal to 18 years of age with liver cirrhosis on assessment for liver transplant

You may not qualify if:

  • multi-organ transplant

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Toronto General Hospital

Toronto, Ontario, M5G 2N2, Canada

Location

MeSH Terms

Conditions

Liver Cirrhosis

Condition Hierarchy (Ancestors)

Liver DiseasesDigestive System DiseasesFibrosisPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 13, 2026

First Posted

October 21, 2026

Study Start

April 1, 2026

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2027

Last Updated

October 21, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will not share

Locations

CA(1)