Radial Artery Dimensions and the Effect of Anaesthetic Induction in Morbid Obesity

NCT07868978 | Completed

• 2 other identifiers: 7210985583045809-604.01.02-/A-39
• Study Type: interventional
• Target: 76
• Locations: 1 country
• Sites: 1

Brief Summary

This single-centre prospective study measured the internal diameter of the radial artery and the distance between the skin surface and the arterial lumen by ultrasound in 76 adults with a body mass index of 40 kg/m2 or above who were scheduled for elective surgery under general anaesthesia. Measurements were made 2 cm proximal to the radial styloid process before induction of anaesthesia and again 5 minutes after endotracheal intubation, so that each patient served as their own control. The relationship of these measurements with anthropometric variables was examined. Patients were additionally randomized to radial artery cannulation with either an 18 G or a 20 G cannula, and the two cannula gauges were compared with respect to the time to successful cannulation and the number of skin punctures.

Conditions

Obesity, Morbid Catheterization, Peripheral

Keywords

radial artery; ultrasonography, interventional; anaesthesia, general; arterial cannulation; body mass index

Outcome Measures

Primary Outcomes (1)

• Change in internal diameter of the radial artery

  Internal diameter of the radial artery measured by ultrasound in the long-axis view, 2 cm proximal to the radial styloid process, with the wrist in 45 degrees of extension. The outcome is the within-patient difference between the measurement before induction of anaesthesia and the measurement after intubation.

  Before induction of anaesthesia and 5 minutes after endotracheal intubation

Secondary Outcomes (4)

• Distance between the skin surface and the radial artery lumen

  Before induction of anaesthesia and 5 minutes after endotracheal intubation

• Relationship between arterial dimensions and anthropometric variables

  At the time of the through study completion, an average of 4 months

• Time to successful cannulation

  During radial artery cannulation, immediately after the second ultrasound measurement

• Number of skin punctures required for successful cannulation

  During radial artery cannulation, immediately after the second ultrasound measurement

Study Arms (2)

20 G cannula

ACTIVE COMPARATOR

Radial artery cannulation with a 20 G arterial cannula (outer diameter 1.1 mm, length 32 mm) after the second ultrasound measurement. n = 38

Device: 20 G arterial cannula; Device: 18 G arterial cannula

18 G cannula

ACTIVE COMPARATOR

Radial artery cannulation with an 18 G arterial cannula (outer diameter 1.3 mm, length 45 mm) after the second ultrasound measurement. n = 38.

Device: 20 G arterial cannula; Device: 18 G arterial cannula

Interventions

20 G arterial cannula DEVICE

Ultrasound-guided radial artery cannulation using a 20 G arterial cannula. The probe was placed in the short axis to identify the artery and cannulation was performed in the long axis

18 G cannula; 20 G cannula

18 G arterial cannula DEVICE

Ultrasound-guided radial artery cannulation using an 18 G arterial cannula, by the same technique.

18 G cannula; 20 G cannula

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18 to 60 years
• Body mass index 40 kg/m2 or above
• American Society of Anesthesiologists physical status III
• Scheduled for elective surgery under general anaesthesia

You may not qualify if:

• Refusal to participate
• Haemodynamic instability
• Coronary artery disease
• Peripheral artery disease
• Diabetes mellitus
• Hypertension
• Known radial or ulnar vascular pathology

Sponsors & Collaborators

• Hilal Subaşı Artıran: lead

Study Sites (1)

Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Department of Anaesthesiology and Reanimation Cerrahpaşa Faculty of Medicine, Istanbul University

  Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaş

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Department of Anaesthesiology and Reanimation, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa

Model Details: Observational paired measurement of radial artery dimensions before and after induction of general anaesthesia, with participants randomised to one of two cannula gauges for the subsequent arterial cannulation.

Study Record Dates

• First Submitted: September 30, 2026
• First Posted: October 9, 2026
• Study Start: November 5, 2020
• Primary Completion: March 10, 2021
• Study Completion: March 10, 2021
• Last Updated: October 9, 2026

Record last verified: 2026-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)