Validity and Reliability of the Language Memory Test (LMT) in Belgium

NCT07868887 | Not Yet Recruiting

• 1 other identifier: 26019_LMT-BE
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to evaluate the practical and research utility of a new test assessing language and memory in people with MS. To this end, we are administering the test to a group of 100 individuals with MS who are receiving treatment at the National MS Center Melsbroek. These data will allow us to determine whether scores on the new test correlate with those of established cognitive tests. Subsequently, we will administer the new test to 100 individuals without an MS diagnosis who are matched for age, gender, and education level. This will enable us to assess whether there are significant differences in scores between individuals with MS and those without the diagnosis. One year later, we will re-administer the tests to the participants with MS to determine the extent to which changes in scores on the new test correspond to changes in scores on established tests.

Conditions

Multiple Sclerosis

Outcome Measures

Primary Outcomes (1)

• Language and Memory Test (LMT)

  The LMT is a brief multidomain test assessing finger tapping speed, rapid lexical access, and visuospatial memory, designed for MS populations.

  Baseline, after one week and and after one year

Other Outcomes (2)

• Symbol Digit Modalities Test (SDMT)

  Baseline and after one year

• Cognitive Change Scale (CCS)

  Baseline and after one year

Study Arms (2)

Adults diagnosed with multiple sclerosis

Treated in a the National MS Center rehabilitation center

Adults without MS diagnosis

matched for age, gender and educational level

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult people diagnosed with multiple sclerosis (PwMS), treated in a multidisciplinary rehabilitation program in the National Multiple Sclerosis Center (NMSC) Belgium. Healthy (no MS diagnosis) adults matched for age, gender and education

You may qualify if:

• Native Dutch speaking
• Sufficient visual function (capacity to perceive test stimuli)
• Minimal single hand function to execute test responses
• Cognitive capacity to apprehend test instructions

You may not qualify if:

• Insufficient visual function (capacity to perceive test stimuli)
• Inability to perform single-hand motor movements required to complete the test (e.g., tapping, selecting responses)
• Insufficient cognitive capacity to understand or follow test instructions
• For PwMS:
• \- MS relapse more recently than three months

Sponsors & Collaborators

• Universitair Ziekenhuis Brussel: lead
• National Multiple Sclerosis Center: collaborator

Related Publications (1)

• Leavitt VM, Simani L, Koch M, Morrow SA, Heuer L, Roozbeh M, Roozbeh M, Traynor S. The language and memory test: A brief multidomain digital cognitive measure for multiple sclerosis. Mult Scler. 2025 Oct;31(11):1348-1357. doi: 10.1177/13524585251366096. Epub 2025 Sep 25.

  PMID: 40995746 BACKGROUND

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 5, 2026
• First Posted: October 9, 2026
• Study Start (Estimated): October 19, 2026
• Primary Completion (Estimated): February 1, 2028
• Study Completion (Estimated): February 1, 2028
• Last Updated: October 9, 2026

Record last verified: 2026-09