Body Composition, Urine Protein, and Kidney Blood Flow After Nutritional Counseling in Children With Nutcracker Syndrome

NCT07868406 | Completed

• 1 other identifier: NCS-NUTRITION-01
• Study Type: observational
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

Nutcracker syndrome occurs when the vein carrying blood from the left kidney is compressed between nearby blood vessels. This can cause protein or blood to appear in the urine. This observational study examined changes in body composition, urine protein levels, and kidney Doppler ultrasound measurements in children with nutcracker syndrome who received nutritional counseling during conservative care. Measurements taken at the start of the study were compared with those taken six months later. The study also examined relationships between body composition, urine protein levels, and ultrasound measurements. There was no comparison group.

Conditions

Nutcracker Syndrome, Renal

Keywords

Children; Proteinuria; Body Composition; Nutritional Counseling; Bioelectrical Impedance Analysis; Doppler Ultrasonography

Outcome Measures

Primary Outcomes (1)

• Change in Urinary Protein Excretion

  Urinary protein excretion measured in a timed urine collection and expressed in mg/m²/hour. The change from baseline to six months was assessed.

  Baseline and 6 months

Secondary Outcomes (2)

• Change in Body Composition Parameters

  Baseline and 6 months

• Change in Renal Doppler Parameters

  Baseline and 6 months

Study Arms (1)

Children With Nutcracker Syndrome

Children with a pre-existing diagnosis of nutcracker syndrome who received nutritional counseling during conservative care. Body composition, urinary protein excretion, and renal Doppler parameters were assessed at baseline and six months.

Behavioral: Nutritional Counseling

Interventions

Nutritional Counseling BEHAVIORAL

Children and their parents received verbal and written advice on healthy nutrition, including a diet plan providing adequate calories for the child's age and sex. Dietitian-prepared brochures recommended that carbohydrates provide 45-65% of total calories, protein 10-30%, and fat 25-35%. Foods rich in omega-3 fatty acids, calcium, and iron were recommended. Participants were reassessed six months after the initial counseling.

Children With Nutcracker Syndrome

Eligibility Criteria

• Age: 0 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Children with a pre-existing diagnosis of nutcracker syndrome attending the pediatric nephrology clinic at Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Türkiye. Diagnosis had been established during routine clinical care on the basis of orthostatic proteinuria and renal Doppler findings.

You may qualify if:

• Children with a pre-existing diagnosis of nutcracker syndrome established during routine clinical care on the basis of orthostatic proteinuria and renal Doppler findings.
• Written informed consent from a parent or legal guardian.

You may not qualify if:

• \- Severe intellectual disability.

Sponsors & Collaborators

• Kanuni Sultan Suleyman Training and Research Hospital: lead

Study Sites (1)

Istanbul Kanuni Sultan Suleyman Training and Research Hospital

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Renal Nutcracker Syndrome; Proteinuria

Interventions

Nutrition Assessment

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Urination Disorders; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Epidemiologic Measurements; Public Health; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 3, 2026
• First Posted: October 9, 2026
• Study Start: October 30, 2017
• Primary Completion: September 25, 2018
• Study Completion: September 25, 2018
• Last Updated: October 9, 2026

Record last verified: 2026-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)