THE EFFECT OF CRP/LYMPHOCYTE AND NEUTROPHIL/LYMPHOCYTE RATIOS ON LENGTH OF HOSPITAL STAY AND MORTALITY IN PATIENTS ADMITTED TO THE BURN UNIT

NCT07855432 | Active Not Recruiting DMC

• 1 other identifier: GOKAEK 2026/6/3
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective study aims to evaluate the prognostic value of systemic inflammatory markers, specifically the C-reactive protein-to-lymphocyte ratio (CLR) and neutrophil-to-lymphocyte ratio (NLR), in patients admitted to the burn intensive care unit. Burn injury triggers a profound systemic inflammatory response, which significantly influences clinical outcomes. By analyzing medical records, the study investigates whether admission or dynamic changes in CLR and NLR correlate with the length of hospital stay (LOS) and in-hospital mortality. The ultimate goal is to identify cost-effective, readily available biomarkers for early risk stratification in severe burn management.

Conditions

Burn

Outcome Measures

Primary Outcomes (1)

• In-Hospital Mortality

  Evaluation of the association between baseline CRP/lymphocyte ratio (CLR) and neutrophil/lymphocyte ratio (NLR) values upon admission and the occurrence of all-cause in-hospital mortality.

  01.01.2020 - 31.12.2025

Study Arms (1)

Burn Unit Patients

Adult patients (≥18 years) admitted to the burn intensive care unit whose medical records, including complete blood counts and CRP levels, are evaluated retrospectively.

Other: Routine blood samples collected for CRP, neutrophil, and lymphocyte counts during ICU admission.

Interventions

Routine blood samples collected for CRP, neutrophil, and lymphocyte counts during ICU admission. OTHER

Routinely checked complete blood count and biochemistry tests

Burn Unit Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients (aged 18 years and older) who were admitted to the Burn Intensive Care Unit (BICU) of Samsun Training and Research Hospital between January 2020 and December 2025. Patient data will be extracted retrospectively from electronic medical records. Eligible participants are those with confirmed acute burn injuries whose routine laboratory investigations (complete blood count and C-reactive protein) were performed upon admission.

You may qualify if:

• Patients with missing data
• Patients with chronic inflammatory disease (optional)
• Pediatric patients under 18 years of age
• Patients with a hospital stay of less than one day

You may not qualify if:

• Patients with missing data
• Patients with chronic inflammatory disease (optional)
• Pediatric patients under 18 years of age
• Patients with a hospital stay of less than one day

Sponsors & Collaborators

• Samsun University: lead

Study Sites (1)

Samsun Universitesi

Samsun, Atakum, Turkey (Türkiye)

Location

Related Publications (1)

• Pao-Jen Kuo, Ching-Ya Huang, Kuan-Hao Liao, Ching-Hua Tsai, Wei-Ti Su, Shiun-Yuan Hsu, Ching-Hua Hsieh. Association of C-reactive protein-to-lymphocyte ratio and mortality outcome in patients with trauma admitted to an intensive care unit. Signa Vitae. 2026; 22(2): 96-103. doi: 10.22514/sv.2025.183

  BACKGROUND

MeSH Terms

Conditions

Burns

Condition Hierarchy (Ancestors)

Wounds and Injuries

Study Officials

• Hatice Bahadır Altun

  SAMSUN UNIVERSITESI

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist Doctor

Study Record Dates

• First Submitted: September 28, 2026
• First Posted: October 2, 2026
• Study Start: January 1, 2020
• Primary Completion: December 31, 2025
• Study Completion: September 30, 2026
• Last Updated: October 2, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)