Physical Function Before Surgery and Lung Complications After Lung Surgery

NCT07853430 | Not Yet Recruiting

• 1 other identifier: THOR-FUNC-2026-001
• Study Type: observational
• Target: 450
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will examine whether patients' ability to perform everyday physical activities before lung surgery is related to their risk of developing lung complications after surgery. It will include adults scheduled for surgery to remove part or all of a lung. The main questions are:

• Is lower physical function before surgery associated with a higher risk of lung complications afterward?
• Can information reported by patients improve risk assessment when added to routine clinical information?
• How is physical function before surgery related to recovery afterward? Participants will complete questionnaires about their physical abilities, breathing symptoms, and recovery. Researchers will also collect information from medical records, including lung function tests, anesthesia care, the type of surgery, pain management, and chest drainage. Participants will be followed after surgery to record lung complications and recovery. This is an observational study. The research team will not assign patients to particular treatments or change their usual surgical or anesthesia care. The findings may help identify patients who need closer assessment and additional support around the time of lung surgery.

Conditions

Postoperative Pulmonary Complications (PPCs); Preoperative Functional Status

Outcome Measures

Primary Outcomes (1)

• Incidence of Postoperative Pulmonary Complications

  Within 7 days after surgery

Interventions

Preoperative Functional Status Assessment OTHER

Preoperative functional status will be assessed using the Duke Activity Status Index (DASI), a 12-item questionnaire about the ability to perform daily physical activities. Trained research staff will administer the questionnaire before surgery. The total score will be analyzed primarily as a continuous measure, with higher scores indicating better functional capacity. Questionnaire data will be linked to routine clinical, anesthesia, and surgical information to examine associations with postoperative pulmonary complications and recovery. This assessment is for observational research only; it does not assign treatment or alter routine perioperative care.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults aged 18 years or older scheduled for elective lung resection at Aerospace Center Hospital, Beijing, China, will be consecutively recruited during preoperative assessment. The population will include patients undergoing surgery for benign or malignant lung conditions through video-assisted, robot-assisted, or open approaches. Patients with and without prior neoadjuvant treatment will be eligible. Participants will represent a range of preoperative functional abilities and will be followed through 30 days after surgery.

You may qualify if:

• Age 18 years or older.
• Scheduled for elective lung resection, including wedge resection, segmentectomy, lobectomy, bilobectomy, or pneumonectomy, through a video-assisted, robot-assisted, or open surgical approach.
• Able to understand and answer the study questionnaires in Chinese, independently or with standardized assistance from research staff.
• Willing to participate in preoperative assessment and follow-up through 30 days after surgery.
• Provides written informed consent.

You may not qualify if:

• Emergency surgery.
• Planned concomitant major surgery involving another organ, such as esophagectomy or cardiac surgery.
• Active respiratory infection diagnosed before surgery.
• Cognitive impairment or another condition that prevents informed consent or reliable self-reported questionnaire responses despite assistance.

Sponsors & Collaborators

• Aerospace Center Hospital: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 26, 2026
• First Posted: October 1, 2026
• Study Start (Estimated): November 10, 2026
• Primary Completion (Estimated): March 10, 2027
• Study Completion (Estimated): March 25, 2027
• Last Updated: October 1, 2026

Record last verified: 2026-09