Clinical, Electrophysiological and Genetic Characteristics of Hereditary and Inflammatory Polyneuropathies in France

NCT07851844 | Not Yet Recruiting

• 1 other identifier: APHP260582
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 26

Brief Summary

To describe the clinical, electrophysiological, and genetic characteristics of patients with genetic and inflammatory polyneuropathies in France.

Conditions

Genetic and Inflammatory Polyneuropathies

Keywords

Rare Diseases; Genetic Testing; Electrophysiology; Chronic Inflammatory Demyelinating Polyradiculoneuropathy; Charcot-Marie-Tooth Disease; Inflammatory Neuropathy; Hereditary Neuropathy; Polyneuropathy

Outcome Measures

Primary Outcomes (1)

• Number and percentage of participants by type of polyneuropathy

  Participants will be classified as having genetic or inflammatory polyneuropathy according to the diagnosis documented in their medical records. The number and percentage of participants in each category will be reported.

  At inclusion, based on the diagnosis documented in the medical record.

Secondary Outcomes (5)

• Number and percentage of participants by polyneuropathy subtype

  At inclusion, based on the diagnosis documented in the medical record.

• Demographic characteristics of patients

  At baseline, corresponding to the date of inclusion in the study, using data available in the medical record up to that date.

• Geographical distribution of patients

  At baseline, corresponding to the date of inclusion in the study, using data available in the medical record up to that date.

• Number and percentage of participants by electrophysiological neuropathy pattern

  At inclusion, based on electrophysiological examinations available in the medical record.

• Genetic abnormalities

  At baseline, corresponding to the date of inclusion in the study, using genetic data available in the medical record up to that date.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults diagnosed with genetic or inflammatory polyneuropathy and followed in participating neurology centers in France.

You may qualify if:

• Adult patients aged 18 years or older.
• Patients with a diagnosis of genetic or inflammatory polyneuropathy, confirmed by complementary examinations performed as part of routine care, including genetic, biological and/or electrophysiological tests.

You may not qualify if:

• \- Patient opposition to the use of their routine care data for research purposes.

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (26)

CHU Amiens-Picardie - Site Sud

Amiens, France

Location

CHU Angers

Angers, France

Location

Hôpital Pellegrin, CHU Bordeaux

Bordeaux, France

Location

Hôpital Morvan, CHU Brest

Brest, France

Location

Hôpital Pierre Wertheimer, HCL

Bron, France

Location

Hôpital Gabriel-Montpied, CHU Clermont-Ferrand

Clermont-Ferrand, France

Location

Hôpital François Mitterrand, CHU Dijon

Dijon, France

Location

Centre Hospitalier Annecy Genevois

Épagny, France

Location

Hôpital Raymond-Poincaré

Garches, France

Location

CHU Grenoble - Site Sud

Grenoble, France

Location

CHU de la Réunion - GH Sud Réunion - Saint-Pierre

La Réunion, France

Location

Hôpital Bicêtre

Le Kremlin-Bicêtre, France

Location

Hôpital Salengro, CHU de Lille

Lille, France

Location

Hôpital Dupuytren, CHU Limoges

Limoges, France

Location

Hôpital de la Timone, AP-HM

Marseille, France

Location

F-Esselin@Chu-Montpellier.Fr

Montpellier, France

Location

CHU Nantes - Hôtel-Dieu - Hôpital Mère-Enfant

Nantes, France

Location

Hôpital Pasteur, CHU Nice

Nice, France

Location

Hôpital Universitaire Carémeau, CHU Nîmes

Nîmes, France

Location

Hôpital Ambroise Paré

Paris, France

Location

Hôpital La Pitié-Salpetrière

Paris, France

Location

Hôpital Maison Blanche, CHU Reims

Reims, France

Location

Hôpital Charles-Nicolle, CHU Rouen

Rouen, France

Location

Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg

Strasbourg, France

Location

Hôpital Rangueil, CHU Toulouse

Toulouse, France

Location

Hôpital Bretonneau CHRU de Tours

Tours, France

Location

MeSH Terms

Conditions

Neuritis; Rare Diseases; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Charcot-Marie-Tooth Disease; Polyneuropathies

Condition Hierarchy (Ancestors)

Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Polyradiculoneuropathy; Autoimmune Diseases of the Nervous System; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Chronic Disease; Hereditary Sensory and Motor Neuropathy; Nervous System Malformations; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Genetic Diseases, Inborn

Central Study Contacts

Andoni ECHANIZ-LAGUNA

CONTACT

+33(0)145212677; andoni.echaniz-laguna@aphp.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 22, 2026
• First Posted: October 1, 2026
• Study Start (Estimated): November 1, 2026
• Primary Completion (Estimated): November 1, 2036
• Study Completion (Estimated): November 1, 2036
• Last Updated: October 1, 2026

Record last verified: 2026-06

Locations

FR (26)