Stromal Desmoplastic Reaction as a Predictive Factor for Lymph Node Metastasis in Medullary Thyroid Cancer

NCT07851324 | Not Yet Recruiting

• 2 other identifiers: DESMED studyDESMED
• Study Type: observational
• Target: 74
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a prospective multicenter observational study on medullary thyroid cancer , aiming to investigate the correlation of stromal desmoplastic reaction with tumor aggressiveness.

Conditions

Medullary Thyroid Carcinoma

Keywords

medullary thyroid cancer; stromal desmoplastic reaction; desmoplasia; lymph node metastasis

Outcome Measures

Primary Outcomes (1)

• Number of patients with absence of Desmoplastic stromal reaction and metastatic lymph node in central and lateral compartment

  Number of patients with absence of Desmoplastic stromal reaction and metastatic lymph node in central and lateral compartment

  Perioperative/ From the end of the surgery to the pathology report results that characterizes this outcome

Secondary Outcomes (1)

• Factors like baseline calcitonin levels, extrathyroidal extension, lymphovascular and capsular invasion that correlate with lymph node metastasis in medullary thyroid cancer

  From baseline to up to 3 months postoperatively

Interventions

lobectomy with lymph node dissection PROCEDURE

This operation is the one suggested by the guidelines for medullary thyroid cancer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with medullary thyroid cancer that will undergo surgery as curative method

You may qualify if:

• Patients who underwent thyroidectomy for medullary thyroid cancer (total thyroidectomy) +/- central/lateral neck dissection
• Sporadic medullary thyroid cancer

You may not qualify if:

• Age \< 18 years
• Hereditary medullary thyroid cancer cases
• Patients that do not undergo central or lateral lymph node dissection
• Patient unwillingness to participate in this study
• Incomplete follow-up
• Patient is participating in another clinical trial which may affect this study's outcomes

Sponsors & Collaborators

• University of Pisa: collaborator
• Universita di Verona: collaborator
• University of Cagliari: collaborator
• Aristotle University Of Thessaloniki: lead
• Fondazione Policlinico Universitario Agostino Gemelli IRCCS: collaborator

MeSH Terms

Conditions

Carcinoma, Medullary; Fibrosis; Lymphatic Metastasis

Interventions

Lymph Node Excision

Condition Hierarchy (Ancestors)

Carcinoma, Neuroendocrine; Neuroendocrine Tumors; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms, Ductal, Lobular, and Medullary; Neoplasms, Nerve Tissue; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Neoplasm Metastasis; Neoplastic Processes

Intervention Hierarchy (Ancestors)

Surgical Procedures, Operative

Central Study Contacts

Theodossis Papavramidis

CONTACT

+306944536972; papavramidis@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Surgery

Study Record Dates

• First Submitted: September 20, 2026
• First Posted: October 1, 2026
• Study Start: September 30, 2026
• Primary Completion (Estimated): June 30, 2027
• Study Completion (Estimated): June 30, 2027
• Last Updated: October 1, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share