HFNC During Bronchoscopy in COPD Patients

NCT07850856 | Not Yet Recruiting DMC

• 1 other identifier: FAHGuangzhou20260822
• Study Type: interventional
• Target: 1,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Bronchoscopy diagnosis and treatment is highly irritating, and the effect of local topical anesthesia is poor; the airway is shared; and COPD patients have low oxygen reserves due to impaired lung function. At present, clinical anesthesia generally uses nasal cannula for oxygen inhalation. If the anesthesia is too shallow, it may cause airway spasm, and if the anesthesia is too deep, it will inhibit breathing and lead to hypoxia. Hypoxemia has been reported in 66% of COPD patients undergoing sedation for bronchoscopy. Therefore, solving hypoxia is the biggest problem in anesthesia for bronchoscopy diagnosis and treatment.

Conditions

COPD

Keywords

HFNC; COPD

Outcome Measures

Primary Outcomes (1)

• pulse oximetry

  Blood oxygen saturation during anesthesia, record the duration and number of times below 90%

  The entire anesthesia period during bronchoscopy

Study Arms (2)

Group N

OTHER

Group N used traditional nasal cannula to inhale oxygen during anesthesia.

Other: group N used traditional nasal cannula for oxygen inhalation

Group HFNC

EXPERIMENTAL

During anesthesia, the HFNC group used nasal high-flow oxygen inhalation

Other: Group HFNC used nasal high-flow oxygen inhalation.

Interventions

group N used traditional nasal cannula for oxygen inhalation OTHER

1000 COPD patients who underwent bronchoscopy were randomly divided into 2 groups in a 1:1 ratio.Nasal high-flow oxygen therapy group（group N） and nasal cannula oxygen inhalation group(group HFNC）.The N group used traditional nasal cannula for oxygen inhalation, and the HFNC group used nasal high-flow oxygen inhalation.

Group N

Group HFNC used nasal high-flow oxygen inhalation. OTHER

1000 COPD patients who underwent bronchoscopy were randomly divided into 2 groups in a 1:1 ratio.Nasal high-flow oxygen therapy group（group N） and nasal cannula oxygen inhalation group(group HFNC）.The N group used traditional nasal cannula for oxygen inhalation, and the HFNC group used nasal high-flow oxygen inhalation.

Group HFNC

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• COPD ,（ASA）Ⅰ ～ Ⅲ

You may not qualify if:

• Contraindications to bronchoscopy or anesthesia, Nosebleeds

Sponsors & Collaborators

• The First Affiliated Hospital of Guangzhou Medical University: lead

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Open Label
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: deputy chief physician

Model Details: This study compared the effects of nasal cannula oxygen inhalation and high-flow nasal oxygen therapy (HFNC) on bronchoscopy under anesthesia in COPD patients.

Study Record Dates

• First Submitted: August 22, 2026
• First Posted: September 30, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2030
• Last Updated: September 30, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will share
• Time Frame: Beginning 6 months and ending 5 years following publication of primary results.
• Access Criteria: Researchers who provide a methodologically sound proposal. Proposals should be directed to \[your email\]. To gain access, data requestors will need to sign a data access agreement.