Menstrual Cycle, Menopause, and Pain Perception During Endodontic Treatment

NCT07850167 | Recruiting

• 1 other identifier: 2026/10
• Study Type: observational
• Target: 130
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to investigate whether menstrual cycle phases and menopausal status are associated with pain perception in patients undergoing endodontic treatment. The main questions it aims to answer are: Does pain experienced during endodontic treatment differ according to the phase of the menstrual cycle? Is pain perception during endodontic treatment different between premenopausal and postmenopausal women? Are menstrual cycle phases and menopausal status associated with pain experienced after endodontic treatment? Participants undergoing endodontic treatment as part of their routine dental care will provide information about their menstrual cycle or menopausal status. Pain will be assessed at different stages of treatment and during the follow-up period after treatment. No treatment will be assigned based on menstrual cycle phase or menopausal status.

Conditions

Pain Perception in Endodontic Treatment; Menstrual Cycle; Menopause

Outcome Measures

Primary Outcomes (1)

• Pain Intensity Assessed Using the Visual Analog Scale

  Pain intensity will be assessed using the 100-mm Visual Analog Scale (VAS), ranging from 0 to 100 mm, with higher scores indicating greater pain intensity. Pain scores will be compared among participants in the follicular phase, luteal phase, and postmenopausal groups.

  -Before treatment(baseline) -Immediately after local anesthetic injection -Immediately after completion of endodontic treatment -Postoperative Day 1 -Postoperative Day 2

Secondary Outcomes (1)

• Dental Anxiety Assessed Using the Modified Dental Anxiety Scale

  Before endodontic treatment

Study Arms (3)

Follicular Phase Group

Women undergoing routine endodontic treatment who are in the follicular phase of their menstrual cycle.

Luteal Phase Group

Women undergoing routine endodontic treatment who are in the luteal phase of their menstrual cycle.

Postmenopausal Group

Postmenopausal women undergoing routine endodontic treatment.

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: Eligibility is limited to women because the study investigates the association of menstrual cycle phases and postmenopausal status with pain perception during and after endodontic treatment.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Women aged 18 years or older who present to the Department of Endodontics, Faculty of Dentistry, Nigde Omer Halisdemir University and require root canal treatment. Eligible participants who voluntarily agree to participate will be included and classified according to menstrual cycle phase (follicular or luteal phase) or postmenopausal status.

You may qualify if:

• Willing to participate in the study
• Aged 18 years or older
• Having at least one tooth requiring root canal treatment

You may not qualify if:

• Aged under 18 years
• No tooth requiring root canal treatment
• Male sex
• Diagnosis of endometriosis or polycystic ovary syndrome (PCOS)
• Use of oral contraceptives
• Receiving hormone therapy

Sponsors & Collaborators

• Nigde Omer Halisdemir University: lead

Study Sites (1)

Niğde Omer Halisdemir University

Niğde, Turkey (Türkiye)

RECRUITING

Central Study Contacts

Zübeyde Gökçe Ürün, Assistant Professor

CONTACT

+905378880030; gurun@ohu.edu.tr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: September 22, 2026
• First Posted: September 30, 2026
• Study Start: March 10, 2026
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): March 1, 2027
• Last Updated: September 30, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)