MEMRI: Memory Emergence Using MRI

NCT07849075 | Not Yet Recruiting

• 1 other identifier: 374049
• Study Type: observational
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

Episodic memory is our ability to remember personal experiences, such as a birthday party or a visit to the park. This study aims to understand how this type of memory develops during the first two years of a baby's life. Researchers will use a safe, non-invasive brain scanning technique called magnetic resonance imaging (MRI) to study healthy babies from birth until they are two years old. By following the same children over time, researchers will see how the brain's memory system develops and how it becomes connected with other parts of the brain. The findings will help us understand how babies develop the ability to remember personal experiences. They will also provide new knowledge about how the human brain develops during the earliest stages of life.

Conditions

Not Applicable - Healthy Participants; Focus is the Memory System; Paediatric

Keywords

Memory; Neonatal; Paediatric; MRI

Outcome Measures

Primary Outcomes (1)

• FMRI connectivity

  Differences in functional connectivity of spontaneous fMRI brain activity

  Two years

Secondary Outcomes (1)

• Changes in fMRI connectivity

  Two years

Eligibility Criteria

• Age: 0 Weeks - 1 Week
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Participants in this study will be infants born at the John Radcliffe Hospital, Oxford at or after 35+0 weeks gestation with a postnatal age of \<7 days.

You may qualify if:

• Infants born at the John Radcliffe Hospital, Oxford
• Infants born at or after 35+0 weeks gestation
• Infants with a postnatal age of \<7 days
• Infants for whom parents/legal guardians have given written informed consent for participation.

You may not qualify if:

• Hypoxic Ischaemic Encephalopathy (HIE)
• Intraventricular haemorrhage (IVH) \> grade II
• Received any analgesics or sedatives in the last 24 hours
• Congenital malformation or genetic condition known to affect neurological development
• Born to mothers who have a history of substance abuse
• Any MRI contradictions

Sponsors & Collaborators

• Paediatric Neuroimaging Research Group: lead

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 26 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 24, 2026
• First Posted: September 30, 2026
• Study Start (Estimated): March 1, 2027
• Primary Completion (Estimated): March 1, 2030
• Study Completion (Estimated): July 1, 2031
• Last Updated: September 30, 2026

Record last verified: 2026-09