Can Exercise Electrocardiography Discriminate Hypertensive Heart Disease From Obstructive Coronary Artery Disease? A Multimodality Imaging Study

NCT07847463 | Recruiting

• 1 other identifier: HYSTERESIS
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the ability of exercise ECG to discriminate between hypertensive heart disease-related and CAD-related abnormalities

Conditions

Obstructive Coronary Artery Disease; Left Ventricular Hypertrophy

Keywords

exercise ECG; LVH; CCTA; Stress CMR; CAD; transthoracic echocardiography; TTE

Outcome Measures

Primary Outcomes (1)

• diagnostic performance of exercise ECG across the four predefined groups.

  Differences in ECG response patterns will be compared according to the presence of LVH and obstructive CAD. Multivariable analysis will be performed to identify independent ECG predictors associated with obstructive CAD and inducible ischemia.

  From enrollment through completion of all diagnostic evaluations, assessed up to 3 months after enrollment.

Study Arms (4)

LVH with obstructive CAD

LVH with obstructive CAD

LVH without obstructive CAD

LVH without obstructive CAD

No LVH with obstructive CAD

No LVH with obstructive CAD

No LVH without obstructive CAD

No LVH without obstructive CAD

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

consecutive patients undergoing evaluation for suspected coronary artery disease will undergo exercise ECG testing (ExECG), transthoracic echocardiography (TTE), stress cardiac magnetic resonance (CMR), and coronary computed tomography angiography (CCTA). Patients will be stratified into four groups according to the presence or absence of LVH and obstructive CAD: LVH with obstructive CAD LVH without obstructive CAD No LVH with obstructive CAD No LVH without obstructive CAD

You may qualify if:

• Patients with CAD and LVH

You may not qualify if:

• Patients with RBBB

Sponsors & Collaborators

• University of Pisa: lead

Study Sites (1)

Azienda Ospedaliero-Universitaria Pisana

Pisa, PI, 56124, Italy

RECRUITING

MeSH Terms

Conditions

Hypertrophy, Left Ventricular

Condition Hierarchy (Ancestors)

Cardiomegaly; Heart Diseases; Cardiovascular Diseases; Hypertrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 12 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhDs

Study Record Dates

• First Submitted: September 18, 2026
• First Posted: September 29, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): September 1, 2028
• Study Completion (Estimated): September 1, 2029
• Last Updated: September 29, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)