Assessment of Vitiligo Lesions Using Polarized Dermoscopy, Sub-Ultraviolet Reflectance Dermoscopy, and Ultraviolet Dermoscopy

NCT07846969 | Recruiting

• 1 other identifier: IstanbulTRH-DERM-VITSUV-2026
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn how different close-up skin imaging methods show vitiligo spots in adults with vitiligo. The study will look at skin changes that may be related to whether a vitiligo spot is active, stable, or gaining color again. The main question it aims to answer is: Can special light-based imaging methods show useful details of vitiligo spots differently than regular polarized dermoscopy? Participants will have vitiligo spots photographed during one study visit. Researchers will take images using polarized dermoscopy, sub-ultraviolet reflectance imaging, and ultraviolet fluorescence dermoscopy. Dermatologists will later review the coded images and score how clearly selected skin features can be seen. The study will not change participants' treatment. It will not include blood tests, biopsy, injections, or any other invasive procedure.

Conditions

Vitiligo

Keywords

Dermoscopy; Sub-ultraviolet reflectance imaging; Ultraviolet fluorescence dermoscopy; Vitiligo activity; Vitiligo stability; Vitiligo morphological findings; Repigmentation; Polarized dermoscopy

Outcome Measures

Primary Outcomes (1)

• Comparison of total visibility scores between polarized dermoscopy and sub-ultraviolet reflectance dermoscopy

  For each participant, the index lesion will be evaluated in polarized dermoscopy and sub-ultraviolet reflectance dermoscopy images. Selected lesion morphology items on the finalized scoring form will be scored from 0 to 3, where 0 indicates absent or not visible and 3 indicates clearly visible. A total visibility score will be calculated for each modality, and the paired within-lesion difference between the two modalities will be analyzed.

  Day 1

Secondary Outcomes (4)

• Visibility scores of individual lesion morphology items across imaging modalities

  Day 1

• Detection rates of individual lesion morphology items after dichotomization of visibility scores

  Day 1

• Assessment of ultraviolet and sub-ultraviolet optical findings

  Day 1

• Inter-rater agreement for lesion morphology assessment

  Through completion of image evaluation, up to 6 months

Study Arms (1)

Adults With Vitiligo

Adult participants with clinically diagnosed vitiligo who will undergo close-up dermoscopic imaging of one to three clinically suitable vitiligo lesions during a single study visit

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with clinically diagnosed vitiligo who attend the dermatology outpatient clinic and have at least one clinically suitable non-genital vitiligo lesion for dermoscopic imaging.

You may qualify if:

• Adults aged 18 years or older
• Clinical diagnosis of vitiligo
• Presence of at least one clinically suitable non-genital vitiligo lesion for dermoscopic imaging
• Ability and willingness to provide written informed consent

You may not qualify if:

• Uncertain clinical diagnosis of vitiligo or presence of another hypopigmented or depigmented disorder that may interfere with lesion evaluation
• Absence of any clinically suitable non-genital vitiligo lesion for imaging
• Inability to cooperate with the imaging procedure
• Refusal or inability to provide written informed consent

Sponsors & Collaborators

• Istanbul Training and Research Hospital: lead

Study Sites (1)

University of Health Sciences Istanbul Training and Research Hospital

Istanbul, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Vitiligo

Condition Hierarchy (Ancestors)

Hypopigmentation; Pigmentation Disorders; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Ayşe Esra Koku Aksu, Professor

  University of Health Sciences Istanbul Training and Research Hospital, Dermatology Department

  STUDY CHAIR

Central Study Contacts

Sueda Şanlı Arıkan, Dermatology Resident Physician

CONTACT

+90 5362483355; sueda.sanli.md@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dermatology Resident Physician

Study Record Dates

• First Submitted: September 23, 2026
• First Posted: September 29, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: September 29, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)