NCT07844681

Brief Summary

This study will compare surgical site infection after linear repair with or without cyanoacrylate skin adhesive following Mohs micrographic surgery or wide local excision. Adult participants undergoing Mohs micrographic surgery or wide local excision for skin cancer with a surgical defect suitable for linear repair will be stratified by suture type and randomized to standardized running epidermal suture closure with or without cyanoacrylate skin adhesive. The primary outcome is surgical site infection within 30 days after surgery. Secondary outcomes include scar quality, treatment satisfaction, wound care burden, wound healing characteristics, antibiotic use, culture results, health care utilization related to wound concerns, and adverse events.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
300

participants targeted

Target at P75+ for not_applicable

Timeline
30mo left

Started Oct 2026

Typical duration for not_applicable

Geographic Reach
1 country

3 active sites

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 21, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

September 28, 2026

Completed
3 days until next milestone

Study Start

First participant enrolled

October 1, 2026

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2028

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 30, 2029

Last Updated

September 28, 2026

Status Verified

September 1, 2026

Enrollment Period

2.2 years

First QC Date

September 21, 2026

Last Update Submit

September 21, 2026

Conditions

Surgical Site InfectionSkin CancerWound Healing

Keywords

Cyanoacrylate skin adhesive2-octyl cyanoacrylateMMSMohs micrographic surgerySurgical site infectionWound care burdenAntibiotic use

Outcome Measures

Primary Outcomes (1)

  • Surgical Site Infection Within 30 Days After Linear Repair

    Surgical site infection will be assessed within 30 days following linear repair after Mohs micrographic surgery or wide local excision. Surgical site infection is defined as culture-confirmed infection or strong clinical suspicion of infection when a culture cannot be obtained, including purulent discharge, erythema with edema or warmth, drainage consistent with infection, or cellulitis requiring antibiotic therapy.

    Within 30 days after Mohs micrographic surgery or wide local excision

Secondary Outcomes (8)

  • Systemic Antibiotic Use

    Baseline through 30 days after surgery

  • Wound Healing Complications

    7 to 14 days and 30 days after surgery

  • Treatment Satisfaction

    2 weeks and 3 months after surgery

  • Wound Care Burden

    2 weeks after surgery

  • Scar Quality

    3 months after surgery

  • +3 more secondary outcomes

Study Arms (6)

Fast Gut Sutures With Adhesive

EXPERIMENTAL

Participants in the absorbable suture stratum will receive standardized running epidermal closure using fast gut sutures followed by cyanoacrylate skin adhesive.

Device: Cyanoacrylate Skin AdhesiveProcedure: Fast Gut Running Epidermal Suture Closure

Fast Gut Sutures Without Adhesive

ACTIVE COMPARATOR

Participants in the absorbable suture stratum will receive standardized running epidermal closure using fast gut sutures without cyanoacrylate skin adhesive.

Procedure: Fast Gut Running Epidermal Suture Closure

Vicryl Rapide Sutures With Adhesive

EXPERIMENTAL

Participants in the absorbable suture stratum will receive standardized running epidermal closure using Vicryl Rapide sutures followed by cyanoacrylate skin adhesive.

Device: Cyanoacrylate Skin AdhesiveProcedure: Vicryl Rapide Running Epidermal Suture Closure

Vicryl Rapide Sutures Without Adhesive

ACTIVE COMPARATOR

Participants in the absorbable suture stratum will receive standardized running epidermal closure using Vicryl Rapide sutures without cyanoacrylate skin adhesive.

Procedure: Vicryl Rapide Running Epidermal Suture Closure

Prolene Sutures With Adhesive

EXPERIMENTAL

Participants in the non-absorbable suture stratum will receive standardized running epidermal closure using Prolene sutures followed by cyanoacrylate skin adhesive.

Device: Cyanoacrylate Skin AdhesiveProcedure: Prolene Running Epidermal Suture Closure

Prolene Sutures Without Adhesive

ACTIVE COMPARATOR

Participants in the non-absorbable suture stratum will receive standardized running epidermal closure using Prolene sutures without cyanoacrylate skin adhesive.

Procedure: Prolene Running Epidermal Suture Closure

Interventions

Vicryl Rapide Running Epidermal Suture ClosurePROCEDURE

Standardized running epidermal closure will be performed using Vicryl Rapide absorbable suture material after Mohs micrographic surgery or wide local excision.

Vicryl Rapide Sutures With AdhesiveVicryl Rapide Sutures Without Adhesive
Fast Gut Running Epidermal Suture ClosurePROCEDURE

Standardized running epidermal closure will be performed using fast gut absorbable suture material after Mohs micrographic surgery or wide local excision.

Fast Gut Sutures With AdhesiveFast Gut Sutures Without Adhesive
Cyanoacrylate Skin AdhesiveDEVICE

Cyanoacrylate skin adhesive will be applied in a thin, continuous layer along the repaired wound after hemostasis and epidermal closure are complete. The adhesive is an FDA-approved topical wound closure product used within its labeled indication.

Also known as: 2-Octyl Cyanoacrylate
Fast Gut Sutures With AdhesiveProlene Sutures With AdhesiveVicryl Rapide Sutures With Adhesive
Prolene Running Epidermal Suture ClosurePROCEDURE

Standardized running epidermal closure will be performed using Prolene non-absorbable suture material after Mohs micrographic surgery or wide local excision.

Prolene Sutures With AdhesiveProlene Sutures Without Adhesive

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age 18 years or older
  • Undergoing Mohs micrographic surgery or wide local excision for skin cancer
  • Surgical defect suitable for linear repair
  • Surgical defect suitable for linear repair using standardized running epidermal sutures
  • Ability to provide informed consent
  • Ability to read at a 5th grade level or above, needed for survey administration

You may not qualify if:

  • Requirement for flap, graft, geometric repair, or healing by second intention
  • Active infection or severe contamination at the surgical site prior to closure
  • Known allergy or hypersensitivity to cyanoacrylate adhesive, fast gut, Vicryl Rapide, or Prolene
  • Recurrent tumor at the surgical site
  • Prior radiation therapy to the surgical site
  • Current use of systemic antibiotics for an unrelated medical condition at the time of surgery
  • Concurrent participation in another interventional research study that could confound wound healing or infection outcomes
  • Inability to comply with study procedures or follow-up visits
  • Any condition that, in the judgment of the investigator, would interfere with safe participation or interpretation of study outcomes
  • Children
  • Fetuses
  • Neonates
  • Prisoners
  • Adults lacking capacity to consent or adults with diminished or fluctuating capacity to consent
  • Non-English speakers
  • +2 more criteria

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Oxboro Dermatology Clinic

Minneapolis, Minnesota, 55420, United States

Location

University of Minnesota Dermatologic Surgery Clinic - CSC

Minneapolis, Minnesota, 55455, United States

Location

University of Minnesota Dermatologic Surgery Clinic - MG

Minneapolis, Minnesota, 55455, United States

Location

MeSH Terms

Conditions

Surgical Wound InfectionSkin Neoplasms

Condition Hierarchy (Ancestors)

Wound InfectionInfectionsPostoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsNeoplasms by SiteNeoplasmsSkin DiseasesSkin and Connective Tissue Diseases

Study Officials

  • Chandler Rundle, MD

    University of Minnesota

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Chandler Rundle, MD

CONTACT

612-625-8625rundle1@umn.edu

Andrew Fay

CONTACT

612-625-8625afay@umn.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: Participants undergoing Mohs micrographic surgery or wide local excision with a surgical defect suitable for linear repair will be stratified by suture type and randomized to standardized running epidermal suture closure with or without cyanoacrylate skin adhesive. Within the absorbable suture stratum, participants will be randomized to fast gut or Vicryl Rapide and to adhesive use or no adhesive. Within the non-absorbable suture stratum, participants will receive Prolene and will be randomized to adhesive use or no adhesive.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 21, 2026

First Posted

September 28, 2026

Study Start

October 1, 2026

Primary Completion (Estimated)

December 30, 2028

Study Completion (Estimated)

March 30, 2029

Last Updated

September 28, 2026

Record last verified: 2026-09

Locations

US(3)