3D MRE-Based Evaluation of Vestibular Schwannoma Mechanical Properties and Histological Features

NCT07844460 | Enrolling By Invitation DMC

• 1 other identifier: 2026_Vestibular Schwannoma
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with vestibular schwannoma undergoing surgical resection. By correlating preoperative MRE-derived stiffness and adhesion maps with intraoperative findings and histopathological features, the study seeks to determine whether MRE can serve as a noninvasive imaging biomarker for risk stratification and prediction of tumor behavior, and to evaluate the relationship between MRE characterization of tumor mechanical features and patients' clinical prognosis.

Conditions

Vestibular Schwannoma

Keywords

Stiffness; Adhesion; Neurosurgery; Vestibular schwannoma; Magnetic resonance elastography

Outcome Measures

Primary Outcomes (1)

• Agreement Between MRE Stiffness and Intraoperative Tumor Consistency

  The primary outcome is the correlation between preoperative 3D MRE-derived shear stiffness values and intraoperative tumor consistency as assessed by the neurosurgeon using a standardized ordinal scale (1-5). Agreement will be evaluated using Spearman correlation and Bland-Altman analysis.

  Intraoperative (Day of Surgery)

Study Arms (1)

MRE diagnostic test group

Participants in this group will undergo preoperative three-dimensional magnetic resonance elastography (3D MRE) . MRE will be used to quantify tumor stiffness and generate a three-dimensional adhesion map. The facial nerve function after surgery will be followed up 3 - 6 months after the operation.

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will enroll adult patients with unilateral sporadic vestibular schwannoma who are scheduled to undergo microsurgical resection at Shengjing hospital.

You may not qualify if:

• Patients with metallic implants or foreign bodies in their bodies (pacemakers, artificial metallic heart valves, metal joints, metal implants, and those who can not remove dentures, insulin pumps, or contraceptive rings) Pregnant women in the first trimester (within three months) Patients with severe claustrophobia or anxiety Patients with severe fever Patients who can not tolerate MRE Patients with vascular malformations and aneurysms. Patients who do not sign an informed consent

Sponsors & Collaborators

• Shengjing Hospital: lead

Study Sites (1)

Shengjing hospital

Shenyang, Liaoning, 110000, China

Location

Related Publications (3)

• Cheng W, Bai S, Zeng Y, Zheng K, Hong Y, Han S, Zhang T, Guo M, Liu T, Wu J, Manduca A, Huston Iii J, Sheng Y, Wu Q, Jiao N, Yin Z, Shi Y, Wu A. Magnetic resonance elastography characterization of meningioma mechanical properties for improved neurosurgical planning and resection a prospective cohort study. Int J Surg. 2025 Dec 11. doi: 10.1097/JS9.0000000000004199. Online ahead of print.

  PMID: 41376349 BACKGROUND

• Duhon BH, Thompson K, Fisher M, Kaul VF, Nguyen HT, Harris MS, Varadarajan V, Adunka OF, Prevedello DM, Kolipaka A, Ren Y. Tumor biomechanical stiffness by magnetic resonance elastography predicts surgical outcomes and identifies biomarkers in vestibular schwannoma and meningioma. Sci Rep. 2024 Jun 24;14(1):14561. doi: 10.1038/s41598-024-64597-1.

  PMID: 38914647 BACKGROUND

• Yin Z, Glaser KJ, Manduca A, Van Gompel JJ, Link MJ, Hughes JD, Romano A, Ehman RL, Huston J 3rd. Slip Interface Imaging Predicts Tumor-Brain Adhesion in Vestibular Schwannomas. Radiology. 2015 Nov;277(2):507-17. doi: 10.1148/radiol.2015151075. Epub 2015 Aug 6.

  PMID: 26247776 RESULT

MeSH Terms

Conditions

Neuroma, Acoustic; Tissue Adhesions

Condition Hierarchy (Ancestors)

Neurilemmoma; Neuroendocrine Tumors; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neuroma; Nerve Sheath Neoplasms; Neoplasms, Nerve Tissue; Cranial Nerve Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Peripheral Nervous System Neoplasms; Vestibulocochlear Nerve Diseases; Retrocochlear Diseases; Ear Diseases; Otorhinolaryngologic Diseases; Otorhinolaryngologic Neoplasms; Cranial Nerve Diseases; Nervous System Diseases; Cicatrix; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Anhua Wu, MD

  Shengjing Hospital

  PRINCIPAL INVESTIGATOR

• wen Cheng, MD

  Shengjing Hospital

  PRINCIPAL INVESTIGATOR

• Yu Shi, MD

  Shengjing Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 21, 2026
• First Posted: September 28, 2026
• Study Start: September 25, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): March 1, 2027
• Last Updated: September 28, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)