Direct Electrical Stimulation of Central Autonomic Network for Blood Pressure Control: a Mechanism Study

NCT07844239 | Not Yet Recruiting DMC

• 1 other identifier: 2025-330-002
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

The primary objective of this research is to study direct electrical stimulation of central autonomic network for blood pressure control.

Conditions

Blood Pressure Control; Hypertension

Keywords

blood pressure control; central autonomic neural network; direct electrical stimulation; hypertension

Outcome Measures

Primary Outcomes (1)

• blood pressure

  Blood Pressure is defined as the blood pressure measurement obtained 30 minutes after the completion of direct electrical stimulation.

  up to 4 hours

Study Arms (1)

Direct electrical stimulation

EXPERIMENTAL

Patients with hypertension and drug-resistant focal epilepsy who underwent intracranial monitoring via stereotactically implanted depth electrodes (SEEG) are assigned to Direct electrical stimulation for 30 sec per mission.

Other: direct electrical stimulation

Interventions

direct electrical stimulation OTHER

The intervention consists of direct electrical stimulation delivered at three distinct frequencies (10 Hz, 50 Hz, and 120 Hz). A double-blind design will be employed to randomly assign one of these frequencies for a 30-second direct electrical stimulation session in each patient.

Direct electrical stimulation

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Aged 18-60 years, with no gender restrictions.
• Free from severe systemic diseases.
• Patients who have undergone stereoelectroencephalography electrode implantation.
• Patients who have been informed of potential risks, consented to participate in this study, and signed the informed consent form.
• Daytime clinic blood pressure fluctuates within the following range: 90 mmHg \< systolic blood pressure \< 140 mmHg; 60 mmHg \< diastolic blood pressure \< 90 mmHg.

You may not qualify if:

• Patients with scalp electrode hematoma or sub-electrode effusion after intracranial electrode implantation, who are unable to receive electrical stimulation.
• Patients with intracranial structural lesions (e.g., encephalomalacia foci, vascular malformations, space-occupying lesions, etc.).
• Pregnant women.
• Patients who are unable to cooperate due to mental disorders or other causes.
• Patients who have participated in other clinical trials within the past 3 months.
• Patients who apply to withdraw from this clinical trial for any reason.
• Patients with cardiac or pulmonary insufficiency.
• Patients with white coat effect are excluded.
• Patients with low cerebrovascular risk assessed by cranial magnetic resonance imaging (MRI).

Sponsors & Collaborators

• Xuanwu Hospital, Beijing: lead

MeSH Terms

Conditions

Hypertension

Interventions

Transcranial Direct Current Stimulation

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Electric Stimulation Therapy; Therapeutics; Convulsive Therapy; Psychiatric Somatic Therapies; Behavioral Disciplines and Activities; Electroshock; Psychological Techniques

Study Officials

• Liankun Ren, MD

  Xuanwu Hospital, Beijing

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Liankun Ren, MD

CONTACT

+86 13681576621; renlk2022@outlook.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 22, 2026
• First Posted: September 28, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: September 28, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share