Comparison of Local Infiltration Anesthesia and Superficial Cervical Plexus Block in Ultrasound-Guided Internal Jugular Vein Catheterization: Efficacy, Duration, and Local Anesthetic Volume - A Randomized Controlled Trial

NCT07841782 | Completed

• 1 other identifier: 2025/81
• Study Type: interventional
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Internal jugular vein (IJV) catheterization is a common invasive procedure performed under ultrasound (USG) guidance. Providing effective analgesia during the procedure is essential for patient comfort. This prospective, randomized controlled study aims to compare the clinical efficacy, onset time, required local anesthetic volume, and hemodynamic stability between ultrasound-guided local infiltration anesthesia (LIA) and ultrasound-guided superficial cervical plexus block (SCPB) using different volumes (2 mL, 5 mL, and 10 mL of 1% lidocaine) in patients undergoing IJV catheterization.

Conditions

Catheterization, Central Venous; Pain, Procedural; Internal Jugular Vein Cannulation

Keywords

central venous catheterizaton, local infiltration anesthesia, superficial cervical plexus block, lidocaine

Outcome Measures

Primary Outcomes (2)

• Time to Effective Block Onset Across Different Local Anesthetic Volumes

  Time elapsed (in seconds) from injection completion until effective analgesia is achieved (defined as an NRS score ≤ 2 via pin-prick test every 5 seconds), evaluating whether lower volumes of SCPB (2 mL and 5 mL) achieve effective block onset in a comparable timeframe to higher volume SCPB (10 mL) and standard LIA (10 mL).

  Evaluated every 5 seconds, up to 5 minutes post-injection.

• Time to Effective Block Onset Across Different Local Anesthetic Volumes

  Time elapsed (in seconds) from injection completion until effective analgesia is achieved (defined as an NRS score ≤ 2 via pin-prick test every 5 seconds), evaluating whether lower volumes of SCPB (2 mL and 5 mL) achieve effective block onset in a comparable timeframe to higher volume SCPB (10 mL) and standard LIA (10 mL).

  Evaluated every 5 seconds, up to 5 minutes post-injection

Secondary Outcomes (1)

• Pain Intensity Across Procedural Stages (NRS Scores)

  At baseline, during infiltration/block injection, during initial needle insertion, and during catheter placement.

Study Arms (4)

Local Infiltration Anesthesia (LIA Group)

ACTIVE COMPARATOR

10 mL of 1% lidocaine hydrochloride is injected subcutaneously over the sternocleidomastoid muscle at the C6 level for local infiltration prior to internal jugular vein catheterization (n=75).

Drug: Lidocaine HCl 1%

Superficial Cervical Plexus Block - 2 mL (SCPB 2 mL)

EXPERIMENTAL

Ultrasound-guided superficial cervical plexus block administered beneath the sternocleidomastoid muscle at the C6 level using 2 mL of 1% lidocaine hydrochloride (n=25).

Drug: Lidocaine HCl 1%

Superficial Cervical Plexus Block - 5 mL (SCPB 5 mL)

EXPERIMENTAL

Ultrasound-guided superficial cervical plexus block administered beneath the sternocleidomastoid muscle at the C6 level using 5 mL of 1% lidocaine hydrochloride (n=25).

Drug: Lidocaine HCl 1%

Superficial Cervical Plexus Block - 10 mL (SCPB 10 mL)

EXPERIMENTAL

Ultrasound-guided superficial cervical plexus block administered beneath the sternocleidomastoid muscle at the C6 level using 10 mL of 1% lidocaine hydrochloride (n=25).

Drug: Lidocaine HCl 1%

Interventions

Lidocaine HCl 1% DRUG

Administration of 1% lidocaine hydrochloride either via ultrasound-guided superficial cervical plexus block (at 2 mL, 5 mL, or 10 mL volumes) or via subcutaneous local infiltration (10 mL) prior to internal jugular vein catheterization.

Also known as: LİDON %2 (diluted %1)

Local Infiltration Anesthesia (LIA Group); Superficial Cervical Plexus Block - 10 mL (SCPB 10 mL); Superficial Cervical Plexus Block - 2 mL (SCPB 2 mL); Superficial Cervical Plexus Block - 5 mL (SCPB 5 mL)

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged between 18 and 80 years
• American Society of Anesthesiologists (ASA) physical status I-III
• Glasgow Coma Scale (GCS) score between 13 and 15
• Patients scheduled for elective or semi-elective ultrasound-guided internal jugular vein catheterization
• Patients who are literate, capable of effective communication, and provide written informed consent

You may not qualify if:

• Glasgow Coma Scale (GCS) score \< 13
• Age \< 18 years or \> 80 years
• ASA physical status IV or higher
• Internal jugular vein catheterization performed under general anesthesia
• Internal jugular vein catheterization performed under emergency conditions
• Distorted head and neck anatomy preventing adequate ultrasound visualization for the block
• Arterial puncture on the first needle insertion attempt
• Illiterate patients or patients unable to establish effective communication to evaluate pain scores
• Known allergy or hypersensitivity to local anesthetics

Sponsors & Collaborators

• Kayseri City Hospital: lead

Study Sites (1)

kayseri City Hospital Department of Anesthesiology and Reanimation

Kayseri, 38080, Turkey (Türkiye)

Location

Related Publications (1)

• Tkle HA, Pat l BM. Comparison of superfical cervical plexus block versus local infiltration for pain relief during internal jugular ven cannulation. Int J Contemp Med Res. 2018;5:I6-12.

  RESULT

MeSH Terms

Conditions

Pain, Procedural

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Outcome measures (NRS pain scores and hemodynamic parameters) and block evaluations are recorded by an independent clinician who is blinded to the patient allocation and group interventions.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Model Details: A prospective, randomized, parallel-group clinical trial with four study arms. Eligible patients undergoing ultrasound-guided internal jugular vein catheterization are randomly allocated using a sealed-envelope method into either the Local Infiltration Anesthesia group (LIA, n=75) or one of the three Superficial Cervical Plexus Block volume subgroups (SCPB 2 mL, SCPB 5 mL, or SCPB 10 mL; n=25 per subgroup).

Study Record Dates

• First Submitted: September 20, 2026
• First Posted: September 25, 2026
• Study Start: June 1, 2025
• Primary Completion: July 1, 2025
• Study Completion: July 1, 2025
• Last Updated: September 25, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)