NCT07841769

Brief Summary

This study will evaluate whether IVF success rates after PRS-based embryo selection differ from those after morphology-based embryo selection, and whether polygenic disease risk correlates with embryo morphology.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,000

participants targeted

Target at P75+ for all trials

Timeline
37mo left

Started Oct 2026

Typical duration for all trials

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 16, 2026

Completed
9 days until next milestone

First Posted

Study publicly available on registry

September 25, 2026

Completed
6 days until next milestone

Study Start

First participant enrolled

October 1, 2026

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 30, 2029

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2029

Last Updated

September 25, 2026

Status Verified

September 1, 2026

Enrollment Period

3 years

First QC Date

September 16, 2026

Last Update Submit

September 21, 2026

Conditions

Polygenic Score

Keywords

Polygenic risk scoringin vitro fertilizationembryo selectionembryo morphology

Outcome Measures

Primary Outcomes (1)

  • Sustained Implantation Rate

    Ongoing pregnancy rate per embryo transfer at the time of discharge from IVF care

    From enrollment to the end of treatment at 8-12 weeks

Secondary Outcomes (1)

  • Polygenic Score correlation with Embryo Morphology

    Through study completion (3 years)

Study Arms (1)

IVF patients using preimplantation genetic testing

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Cases (PRS): IVF patients/couples (intended parents) who elect to use PRS based embryo selection. Controls (Morphology): IVF patients/couples (intended parents) who elect to use morphology based embryo selection.

You may qualify if:

  • Age 18 years or older
  • Undergoing IVF and PGT at any clinic where Nucleus testing is used.
  • Ability to provide informed consent and HIPAA authorization

You may not qualify if:

  • Patients who decline research use of data

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 16, 2026

First Posted

September 25, 2026

Study Start

October 1, 2026

Primary Completion (Estimated)

September 30, 2029

Study Completion (Estimated)

September 30, 2029

Last Updated

September 25, 2026

Record last verified: 2026-09