EFFECTS OF DAILY KEFIR CONSUMPTION DURING MEDICAL NUTRITION THERAPY ON BODY COMPOSITION AND PSYCHOLOGICAL WELL-BEING IN WOMEN WITH OBESITY

NCT07840274 | Completed

• 1 other identifier: 2023/1364
• Study Type: interventional
• Target: 68
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled study evaluated the effects of daily kefir consumption as an adjunct to medical nutrition therapy on body composition, biochemical parameters, gastrointestinal symptoms, bowel habits, and psychological well-being in women with obesity. Participants were randomly assigned to receive either 200 mL of plain kefir daily together with individualized medical nutrition therapy or individualized medical nutrition therapy alone for 12 weeks. Assessments were performed at baseline, week 6, and week 12. The primary outcome was change in body weight. Secondary outcomes included changes in body composition, biochemical parameters, gastrointestinal symptoms, bowel habits, and psychological well-being.

Conditions

Obesity & Overweight; Gut Microbiota; Body Composition

Keywords

kefir; medical nutriton theraphy; Women with obesity; Gastrointestinal symptoms; Psychological well-being; Probiotic

Outcome Measures

Primary Outcomes (1)

• Change in body weight (kg) from baseline to week 12

  Body weight was measured in kilograms using a calibrated digital scale. The primary outcome was the change in body weight from baseline to week 12.

  Baseline and week 12

Secondary Outcomes (13)

• Change in body mass index (kg/m²)

  Baseline and week 12

• Change in body fat percentage

  Baseline and week 12

• Change in fat mass (kg)

  Baseline and week 12

• Change in muscle mass (kg)

  Baseline and week 12

• Change in visceral fat level

  Baseline and week 12

Study Arms (2)

Medical Nutrition Therapy + Kefir

EXPERIMENTAL

Participants received individualized medical nutrition therapy together with 200 mL/day of plain kefir for 12 weeks.

Dietary Supplement: Plain Kefir; Behavioral: Individualized Medical Nutrition Therapy

Medical Nutrition Therapy

ACTIVE COMPARATOR

Participants received individualized medical nutrition therapy alone for 12 weeks.

Behavioral: Individualized Medical Nutrition Therapy

Interventions

Plain Kefir DIETARY_SUPPLEMENT

Participants consumed 200 mL of plain kefir daily for 12 weeks in addition to individualized medical nutrition therapy.

Medical Nutrition Therapy + Kefir

Individualized Medical Nutrition Therapy BEHAVIORAL

Participants received individualized medical nutrition therapy delivered by a registered dietitian throughout the 12-week intervention period.

Medical Nutrition Therapy; Medical Nutrition Therapy + Kefir

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Female participants aged 18 years or older. Diagnosis of obesity (BMI ≥30 kg/m²). Willingness to participate in the study and comply with the intervention protocol.
• Provision of written informed consent.

You may not qualify if:

• Pregnancy or lactation. Current use of antibiotics, probiotic or prebiotic supplements during the study period or within the specified washout period (if applicable in your protocol).
• Presence of severe gastrointestinal, renal, hepatic, endocrine, or other serious chronic diseases that could affect study outcomes.
• Known allergy or intolerance to kefir or dairy products. Inability to comply with the intervention or follow-up procedures.

Sponsors & Collaborators

• Pınar Göbel: lead

Study Sites (1)

Healthy Living Center, Karabük

Karabük, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Obesity; Overweight; Psychological Well-Being

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Personal Satisfaction; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: CARE PROVIDER
• Masking Details: This was an open-label study because participants and investigators were aware of the assigned intervention. No masking was implemented.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assoc Prof Dr

Model Details: Participants were randomly assigned to one of two parallel groups: individualized medical nutrition therapy plus daily kefir consumption or individualized medical nutrition therapy alone. Both interventions were continued for 12 weeks, and outcome measures were assessed at baseline, week 6, and week 12.

Study Record Dates

• First Submitted: September 18, 2026
• First Posted: September 25, 2026
• Study Start: June 1, 2024
• Primary Completion: September 30, 2024
• Study Completion: December 31, 2024
• Last Updated: September 25, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)