Combining Moderate Aerobic Exercise With Inspiratory Muscle Training for Dialysis Patients With Atrial
Antiremodelling Effect of Moderate Intensity Aerobic Combined With Inspiratory Muscle Trainings on Kidney Dialysis With Atrial Fibrillation
1 other identifier
interventional
45
0 countries
N/A
Brief Summary
Statement of the problem: Is there a difference between of inspiratory muscle training with aerobic exercise or inspiratory muscle training for hemodialysis patients with AF?? Purpose of the study: To find out the effect of combined inspiratory muscle training with aerobic exercise OR inspiratorty muscle traiting for hemodialysis CKD patients with atrial fibrillation as regards The following outcomes:
- 1.medical state of patient (heart rate, blood pressure, oxygen saturation)
- 2.lab analysis (GFR, Serum creatinine, blood urea and nitrogen (BUN) and INR)
- 3.maximum Inspiratory pressure (MIP)
- 4.period, duration of dialysis
- 5.short form questionnaire(SF36)
- 6.modified Borg scale
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Sep 2026
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 14, 2026
CompletedFirst Posted
Study publicly available on registry
September 18, 2026
CompletedStudy Start
First participant enrolled
September 20, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 20, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
March 23, 2027
September 18, 2026
September 1, 2026
6 months
September 14, 2026
September 14, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
6 minute walk test
6 minute walk test : (To detect functional capacity, carry out in a 20 -meter line along The passage way, The tape is placed every 30 meters .patients are instructed to walk The longest possible distance in 6 minutes continuously, turning around at The final Mark without stopping. they are further instructed to walk as far as they can for 6minutes without running or jogging, covered distance in meters is measured at the end of the rest for analysis
at the start of study and after intervention (3months)
Study Arms (3)
group A inspiratory muscle training
ACTIVE COMPARATORintervention device(inspiratory muscle training) (inspiratory muscle trainingat 30% of maximal inspiratory pressure for20 minutes/ session, 3 days a week, for 3 months Each patient breathes through a separate mouthpiece. The resistance is adjusted 30% of maximum inspiratory pressure detected from maximum inspiratory pressure meter and is marked on the training device. A single training session consists of five sets, each contains five inspirations with total of twenty five breaths with one minute of recovery between each set. The resistance was adjusted every month at 30%of the new maximum pressura and if it remain the subject remain at the same level
group B (Aerobic exercise+inspiratory muscle trainig )
ACTIVE COMPARATORinterventions device ( Aerobic exercise +inspiratory muscle training) Aerobic exercise only 5-minute warm-up before exercise Each session started with a 5-minute bicycling warmup at 30%- 40% of HRR b) Active phase: * Mode:moderte -intensity interval aerobic training (MIIT). * Intensity: With MODERTE intensity continous of 60 %of heart rate reserve (HRR) monitored by ECG and a 5-minute cool-down following exercise at intensity (30- 40%HR RESERVE) were carried out each time. In addition, the exercise was performed in the first half of the dialysis session over a 3 months period for 3 sessions per week by cycling for 20 min at a moderate intensity(60%HR RESERVE) participants were trained to use stationary bicycle ergometer in a supine position for minimum of 30 minutes at each HD session. The speed, load, and duration were gradually increased with change of mode (automatic and passive). inspiratory muscle training)
control group c receive medical only
NO INTERVENTIONno exercise this group do assessment pre and post 3 months
Interventions
intervention : (inspiratory muscle training) (inspiratory muscle training at 30% of maximal inspiratory pressure for20 minutes/ session, 3 days a week, for 3 months Each patient breathes through a separate mouthpiece. The resistance is adjusted 30% of maximum inspiratory pressure detected from maximum inspiratory pressure meter and is marked on the training device. A single training session consists of five sets, each contains five inspirations with total of twenty five breaths with one minute of recovery between each set. The resistance was adjusted every month at 30%of the new maximum pressura and if it remain the subject remain at the same level
b) Active phase: * Mode:moderte -intensity interval aerobic training (MIIT). * Intensity: With MODERTE intensity continous of 60 %of heart rate reserve (HRR) monitored by ECG and a 5-minute cool-down following exercise at intensity (30- 40%HR RESERVE) were carried out each time. In addition, the exercise was performed in the first half of the dialysis session over a 3 months period for 3 sessions per week by cycling for 20 min at a moderate intensity(60%HR RESERVE) participants were trained to use stationary bicycle ergometer in a supine position for minimum of 30 minutes at each HD session. The speed, load, and duration were gradually increased with change of mode (automatic and passive). inspiratory muscle training)
Eligibility Criteria
You may qualify if:
- Patients from both gender
- With chronic kidney failure(GFR\>30)
- with atrial fibrillation
- Unemployed living a sedentary lifestyle
- Receive regular hemodialysis sessions at 2months ago
- All of them have vascular access through arteriovenous fistula
- Age range from 40-60 years
- Fully understand purpose and procedure of study
- Stable and have sufficient level of cognition and ability to understand instructions
You may not qualify if:
- Real difficulties with understanding and signing The written informed consent
- Recent sequela of cerebrovascular accidents
- Osteoarticular or musculoskeletal diseases
- Un controlled systemic hypertension
- Un controlled diabetes
- Un stable angina
- Fever
- Infectious disease
- Acute respiratory failure
- Recent acute myocardial infarction
- Peripheral vascular diseases
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
sherien H mehani, professor
Beni _suef
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- physiotherapist
Study Record Dates
First Submitted
September 14, 2026
First Posted
September 18, 2026
Study Start
September 20, 2026
Primary Completion (Estimated)
March 20, 2027
Study Completion (Estimated)
March 23, 2027
Last Updated
September 18, 2026
Record last verified: 2026-09
Data Sharing
- IPD Sharing
- Will not share