NCT07826546|Recruiting
Is Central Sensitization a Prognostic Indicator in Chronic Nonspecific Low Back Pain?
The Prognostic Role of Central Sensitization in Short-Term Clinical Outcomes in Chronic Nonspecific Low Back Pain
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The Prognostic Role of Central Sensitization in Short-Term Clinical Outcomes in Chronic Nonspecific Low Back Pain
Sponsor study identifier
observational
180
1 country
1
Study Start
June 1, 2026
Actual (reported)Primary Completion
June 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This observational study will examine whether signs of increased sensitivity in the nervous system at the beginning of the study are associated with short-term clinical outcomes in adults with chronic nonspecific low back pain. Approximately 180 participants will complete questionnaires about central sensitization, disability, pain, anxiety, and depression at the beginning of the study. After 6 weeks, disability, pain, and the participant's overall perception of change will be assessed again. The researchers will evaluate whether the initial level of central sensitization is associated with meaningful improvement in disability and perceived treatment benefit. Participants will not be assigned to a treatment as part of this study and will continue to receive routine clinical care.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 1, 2026
Actual (reported)September 12, 2026
Actual (reported)September 17, 2026
Actual (reported)June 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
June 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Clinically Meaningful Improvement in the Oswestry Disability Index
The proportion of participants who achieve a reduction of at least 30% in the Oswestry Disability Index (ODI) score from baseline. The ODI ranges from 0 to 100, with higher scores indicating greater disability.
Baseline to 6 weeks
Change in the Oswestry Disability Index Score
Baseline to 6 weeks
Change in Pain Intensity
Baseline to 6 weeks
Patient-Perceived Improvement
At 6 weeks
Adults aged 18-65 years with chronic nonspecific low back pain will be evaluated at baseline and followed for 6 weeks. Participants will receive routine clinical care determined by their treating physician. No treatment or intervention will be assigned by the study protocol. Baseline central sensitization symptoms will be evaluated in relation to disability, pain, and perceived improvement at 6 weeks.
Adults aged 18-65 years with chronic nonspecific low back pain lasting for at least 3 months will be recruited from the Physical Medicine and Rehabilitation outpatient clinic of Mardin Training and Research Hospital. Participants will receive routine clinical care and will be evaluated at baseline and after 6 weeks. No healthy control group will be included.
Mardin Training and Research Hospital
Mardin, 47100, Turkey (Türkiye)
Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011 Mar;152(3 Suppl):S2-S15. doi: 10.1016/j.pain.2010.09.030. Epub 2010 Oct 18.
Nijs J, George SZ, Clauw DJ, Fernandez-de-Las-Penas C, Kosek E, Ickmans K, Fernandez-Carnero J, Polli A, Kapreli E, Huysmans E, Cuesta-Vargas AI, Mani R, Lundberg M, Leysen L, Rice D, Sterling M, Curatolo M. Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine. Lancet Rheumatol. 2021 May;3(5):e383-e392. doi: 10.1016/S2665-9913(21)00032-1. Epub 2021 Mar 30.
First Submitted
September 12, 2026
First Posted
September 17, 2026
Study Start
June 1, 2026
Actual (reported)Primary Completion
June 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Contact the study team to confirm eligibility.
Sheenam N, Gaur R, Gonnade NM, Abins TK, Ghosh A, Hussain R. Central sensitisation in chronic low back pain: A cross-sectional study. Indian J Anaesth. 2025 Oct;69(10):1033-1038. doi: 10.4103/ija.ija_433_25. Epub 2025 Sep 5.
Study Completion
June 1, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
September 17, 2026
Record last verified: 2026-09
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